DERIVATIVES OF ANDROSTENE, PHARMACEUTICAL COMPOSITION Russian patent published in 2002 - IPC

FIELD: organic chemistry, steroids, pharmacy. SUBSTANCE: invention relatestoderivativesofandrostene,namely,to17α-dichloroacetoxy-11β-hydroxyandrosta-1,4-diene-carboxylates of the formula (I) where R₁ means C₁-C₄-alkyl possibly substituted with atoms Cl, F, C₁-C₄-alkoxy-group, C₁-C₄-alkylthio-group, C₁-C₄-alkylsulfinyl-group, C₁-C₄-alkylsulfonyl group; R₃ means H, α-OH, β-OH, α-CH₃, β-CH₃, = CH₂, α-OCOCH-Cl₂ or β-OCOCH-Cl₂; R₄ means H, F, Cl; R₅ means H, F, Cl, CH₃; X means -O- or -S-; Z means or β-CH₂Cl; dotted line in ring A means possible 1,2-double bond. Compounds of the formula (I) show anti-inflammatory activity and they can be used for treatment of inflammation in warm-blooded animals. EFFECT: valuable medicinal properties of compounds. 38 cl, 14 tbl, 29 ex