Show metadata Hide metadata

(19)

(11)

2 447 154

(13)

(51)

IPC

C12P33/02(2006-01-01)

C07J1/00(2006-01-01)

C12N1/20(2006-01-01)

(21) (22)

Application

2010137452/10, 2010-09-09

(24)

Start date

2010-09-09

(22)

Actual filing date

2010-09-09

(45)

Published

2012-04-10

(72)

Inventor

Sukhodol'Skaja Galina ViktorovnaSavinova Tat'Jana StepanovnaFokina Viktorija Valer'EvnaShutov Andrej Anatol'EvichNikolaeva Vera MaksimovnaLukashev Nikolaj VadimovichSurovtsev Viktor Vasil'EvichDonova Marina Viktorovna

(73)

Holder

Donova Marina ViktorovnaSukhodol'Skaja Galina ViktorovnaSavinova Tat'Jana StepanovnaLukashev Nikolaj VadimovichSurovtsev Viktor Vasil'Evich

MICROBIOLOGICAL METHOD OF PRODUCING 1,2-DEHYDROGENATED DERIVATIVES OF Δ-3-KETO-STEROIDS OF ANDROSTANE FAMILY IN AQUEUS ORGANIC MEDIA Russian patent published in 2012 - IPC C12P33/02 C07J1/00 C12N1/20

Abstract RU 2447154 C1

FIELD: chemistry.

SUBSTANCE: disclosed is a method of producing 1,2-dehydrogenated derivatives of Δ⁴-3-ketosteroids of the androstane family. A 1,2-dehydrogenation reaction is carried out using cells of a microorganism having high 3-ketosteroid-1-dehydrogenase activity, in a medium containing 8-40 vol. % water miscible aprotic solvent.

EFFECT: invention enables transformation of Δ⁴-3-ketosteroids and ensures high selectivity of formation of 1,2-dehydrogenated Δ⁴-3-ketosteroids at high rates of the process.

4 cl, 1 tbl, 5 ex

Similar patents RU2447154C1

Title	Year	Author	Number
METHOD OF PRODUCING 6-METHYLENEANDROST-4-ENE-3,17-DIONE FROM ANDROST-4-ENE-3,17-DIONE, METHOD OF PRODUCING 6-METHYLENEANDROST-1,4-DIENE-3,17-DIONE (EXEMESTANE) USING OBTAINED 6-METHYLENEANDROST-4-ENE-3,17-DIONE	2010	Savinova Tat'Jana Stepanovna Lukashev Nikolaj Vadimovich Latyshev Gennadij Vladimirovich Sukhodol'Skaja Galina Viktorovna Donova Marina Viktorovna Fokina Viktorija Valer'Evna Shutov Andrej Anatol'Evich Nikolaeva Vera Maksimovna Surovtsev Viktor Vasil'Evich	RU2425052C1
METHOD OF OBTAINING 11BETA, 17 ALPHA, 21-TRIHYDROXY-16ALPHA-METHYL-9ALPHA-FLUOROPREGNA-1,4-DIENE-3,20-DIONE (DEXAMETHAZONE) FROM PHYTOSTEROL	2013	Kazantsev Aleksej Vital'Evich Alexey Vitalievich) Savinova Tat'Jana Stepanovna Tatyana Stepanovna) Lukashev Nikolaj Vadimovich Nikolay Vadimovich) Dovbnja Dmitrij Vladimirovich Dmitry Vladimirovich) Khomutov Sergej Mikhajlovich Sergei Mikhailovich) Sukhodol'Skaja Galina Viktorovna Galina Viktorovna) Shutov Andrej Anatol'Evich Andrei Anatolievich) Fokina Viktorija Valer'Evna Vistoria Valerievna) Nikolaeva Vera Maksimovna Vera Maximovna) Donova Marina Viktorovna Marina Viktorovna) Egorova Ol'Ga Valer'Evna Olga Valerievna) Surovtsev Viktor Vasil'Evich Viktor Vasilievich)	RU2532902C1
METHOD OF PRODUCING 1,2-DEHYDRODERIVATIVES OF 4-DELTA-3-KETO-STEROIDS	1998	Sukhodol'Skaja G.V. Donova M.V. Nikolaeva V.M. Koshcheenko K.A. Dovbnja D.V. Khomutov S.M. Gulevskaja S.A.	RU2156302C1
MICROBIOLOGICAL METHOD OF PRODUCING 21-ACETOXYPREGNA-1,4,9( 11 ),16-TETRAENE-3,20-DIONE FROM 21-ACETOXYPREGNA-4,9( 11 )16-TRIENE-3,20-DIONE	2011	Fokina Viktorija Valer'Evna Sukhodol'Skaja Galina Viktorovna Shutov Andrej Anatol'Evich Nikolaeva Vera Maksimovna Donova Marina Viktorovna Savinova Tat'Jana Stepanovna Lukashev Nikolaj Vadimovich Surovtsev Viktor Vasil'Evich	RU2480475C1
METHOD OF OBTAINING ANDROST-4,9(11)-DIEN-3,17-DIONE FROM PHYTOSTEROL	2012	Kazantsev Alexey Vitalievich Savinova Tatyana Stepanovna Lukashev Nikolay Vadimovich Desyatkin Viktor Grigorievich Dovbnya Dmitry Vladimirovich Khomutov Sergei Mikhailovich Sukhodolskaya Galina Viktorovna Shutov Andrei Anatolievich Donova Marina Viktorovna Egorova Olga Valerievna Surovtsev Viktor Vasilievich	RU2512076C1
METHOD OF OBTAINING 6α-METHYLHYDROCORTISONE OR ITS 11β-ALKANOYLOXY-DERIVATIVES (VERSIONS), METHOD OF OBTAINING 6α-METHYLPREDNISOLONE OR ITS 11β-ALKANOYLOXY-DERIVATIVES USING OBTAINED 6α-METHYLHYDROCORTISONE OR ITS 11β-ALKANOYLOXY-DERIVATIVES	2006	Savinova Tat'Jana Stepanovna Kazantsev Aleksej Vital'Evich Lukashev Nikolaj Vadimovich Arinbasarova Anna Jur'Evna Stepanov Anatolij Ivanovich Skrjabin Georgij Andreevich	RU2337918C9
METHOD OF SYNTHESIS OF STEROID DEHYDROANALOGUES	1992	Koshcheenko Kira Aleksandrovna Arinbasarova Anna Jur'Evna Donova Marina Viktorovna Andrjushina Valentina Aleksandrovna Stytsenko Tat'Jana Semenovna Pashkin Igor' Ivanovich Kuz'Kina Irina Fedorovna Kirsh Jurij Ehrikhovich Karaputadze Timur Musaevich Zubov Vitalij Pavlovich	RU2042687C1
METHOD OF PRODUCING 3β-ACETOXY-17α-HYDROPEROXY-16α-METHYLPREGNANES FROM Δ-20-KETOSTEROIDS AND METHOD OF PRODUCING 3β-ACETOXY-17α-HYDROXY-16α-METHYLPREGNANES USING 3β-ACETOXY-17α-HYDROPEROXY-16α-METHYLPREGNANES	2009	Savinova Tat'Jana Stepanovna Lukashev Nikolaj Vadimovich Beletskaja Irina Petrovna	RU2418805C1
METHOD FOR PREPARING METANDROSTENOLONE	2002	Andrjushina V.A. Arinbasarova A.Ju. Vojshvillo N.E. Savinova T.S. Sazonova A.S. Stytsenko T.S.	RU2236464C2
STRAIN PIMELOBACTER SIMPLEX ELICITING STEROID-1,2-DEHYDROGENASE ACTIVITY	2001	Andrjushina V.A. Vojshvillo N.E. Skrjabin K.G. Stytsenko T.S. Savinova T.S. Sazonova A.S.	RU2215038C2

RU 2 447 154 C1

Authors

Sukhodol'Skaja Galina Viktorovna

Savinova Tat'Jana Stepanovna

Fokina Viktorija Valer'Evna

Shutov Andrej Anatol'Evich

Nikolaeva Vera Maksimovna

Lukashev Nikolaj Vadimovich

Surovtsev Viktor Vasil'Evich

Donova Marina Viktorovna

Dates

2012-04-10—Published

2010-09-09—Filed