INDOLYLMALEIMIDE DERIVATIVES, METHOD OF THEIR OBTAINING, THEIR APPLICATION AND PHARMACEUICAL COMPOSITION FOR TREATMENT OR PREVENTION OF T-LYMPHOCYTE AND/OR "ПКС"- MEDIATED DISORDERS OR DISEASES Russian patent published in 2008 - IPC C07D403/04 C07D403/14 C07D401/14 A61K31/404 A61K31/4709 A61K31/4725 A61P29/00 A61P7/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I) , in which R_a is H, CH₃ or isopropyl, R_b is H, halogen, C_1-6alkoxygroup or C_1-6alkyl, and or I. R is radical of formula (b) , R₄ is 1-pyperasinyl, substituted with CH₃ in positions 3 and/or 4, R_a is not H or CH₃, when R₄ is 4-methyl-1-pyperazinyl; or III. R is remaining part of formula (c) , in which R₁₄ is 1-pyperazinyl, optionally substituted with CH₃ in position 3; or 4,7-diase-spiro[2,5]oct-7-yl, R₁₅ is halogen, CF₃ or CH₃, R₁₅ is not CH₃, when R₁₆ stands for CH₃, R_a is H or CH₃, R_b is H, and R₁₄ is 4-methyl-1-pyperazinyl, and R₁₆ is H, CH₃ or CF₃, R₁₆ is not H, when R₁₅ is Cl, R_a is H or CH₃, R_b is H, and R₁₄ is 4-methyl-1-pyperazinyl, or IV. R is radical of formula (d) , in which R₈ is 1-pyperazinyl, 3- methyl-1-pyperazin-l-yl or 4-benzyl-pyperazin-1-yl, or V. R is radical of formula (e) , in which R₉ is 4,7-diase-spiro[2,5]oct-7-yl or pyperazin-1-yl, substituted in position 3 with ethyl, or its salt, method of their production, based on them pharmaceutical composition and application for obtaining medication for treatment or prevention of T-lymphocyte and-or "ПКС"-mediated diseases or disorders.

EFFECT: increase of composition and treatment method efficiency.

12 cl, 5 tbl, 32 ex