QUINOLINE DERIVATIVES AS SMO INHIBITORS Russian patent published in 2019 - IPC C07D401/10 C07D401/12 C07D401/14 C07D405/12 C07D413/10 C07D413/12 C07D413/14 C07D417/12 C07D417/14 C07D471/04 C07D471/08 C07D487/04 C07D491/08 C07D498/08 A61K31/4725 A61K31/496 A61K31/5377 A61K31/5383 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt thereof, where A is selected from

, , ,, ;

each of T_11-13 is independently selected from N, C(R₁₃); where T_11-13 are C(R₁₃) or one or two of T_11-13 are N, and the rest of T_11-13 are C(R₁₃); T₁₄ and T₁₇ are N; each of T₁₅ and T₁₆ are CH; each of E_11-12 is independently selected from N(CH₃); L₁ is a single bond; L₂ is selected from a single bond or C(=O)NH; R₁₁ is selected from H or methyl; R₁₂ is selected from H, methyl, F, Cl; R₁₃ is selected from H, methyl, trifluoromethyl, trifluoromethoxy, F, Cl, CN, methylaminocarbonyl, methylsulphonyl, morpholinylsulphonyl, 2-imidazolyl or dimethylamino; Q₁₂ is selected from phenyl; where structural unit

and B are selected from structures specified in claim 1. Invention also relates to specific compounds of formula (I).

(I).

EFFECT: technical result is obtaining novel heterocyclic compounds, useful as hedgehog pathway inhibitors, especially as SMO inhibitors and accordingly are effective in treating cancer.

14 cl, 22 tbl