FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt thereof, where A is selected from
,
,
,
,
;
each of T11-13 is independently selected from N, C(R13); where T11-13 are C(R13) or one or two of T11-13 are N, and the rest of T11-13 are C(R13); T14 and T17 are N; each of T15 and T16 are CH; each of E11-12 is independently selected from N(CH3); L1 is a single bond; L2 is selected from a single bond or C(=O)NH; R11 is selected from H or methyl; R12 is selected from H, methyl, F, Cl; R13 is selected from H, methyl, trifluoromethyl, trifluoromethoxy, F, Cl, CN, methylaminocarbonyl, methylsulphonyl, morpholinylsulphonyl, 2-imidazolyl or dimethylamino; Q12 is selected from phenyl; where structural unit
and B are selected from structures specified in claim 1. Invention also relates to specific compounds of formula (I).
(I).
EFFECT: technical result is obtaining novel heterocyclic compounds, useful as hedgehog pathway inhibitors, especially as SMO inhibitors and accordingly are effective in treating cancer.
14 cl, 22 tbl
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Authors
Dates
2019-07-29—Published
2015-03-16—Filed