Show metadata Hide metadata

(19)

(11)

2 340 617

(13)

(51)

IPC

C07D495/04(2006-01-01)

C07D487/04(2006-01-01)

C07D471/14(2006-01-01)

C07D471/04(2006-01-01)

A61K31/5517(2006-01-01)

A61K31/495(2006-01-01)

A61P15/04(2006-01-01)

A61P15/10(2006-01-01)

(21) (22)

Application

2005122323/04, 2004-02-12

(24)

Start date

2004-02-12

(22)

Actual filing date

2004-02-12

(45)

Published

2008-12-10

(72)

Inventor

Khadson PiterBatt Andzhej RomanKhini Selin Margerit SajmonBakster Ehndrju DzhonRou Majkl BrajanRobson Piter Ehndrju

(73)

Holder

Ferring B.V.

BENZAMIDE DERIVATIVES AS OXYTOCIN AGONISTS AND VASOPRESSIN ANTAGONISTS Russian patent published in 2008 - IPC C07D495/04 C07D487/04 C07D471/14 C07D471/04 A61K31/5517 A61K31/495 A61P15/04 A61P15/10

Abstract RU 2340617 C2

FIELD: chemistry.

SUBSTANCE: novel compounds are selected from group, consisting of: 4-(2-cyclopropyl-ethyl)-piperazine-1-carboxylic acid 2-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclopropylmethyl-piperazine-1-carboxylic acid 3-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclopropylmethyl-piperazine-1-carboxylic acid 3-fluorine-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-(2-hydroxymethyl-cyclopropylmethyl)-piperazine-1-carboxylic acid 2-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclopentylmethyl-piperazine-1-carboxylic acid 2-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclopropylmethyl-piperazine-1-carboxylic acid 3-chlorine-4-(3-methyl- 4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclobutylmethyl-piperazine-1-carboxylic acid 3-chlorine-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclobutylmethyl-piperazine-1-carboxylic acid 2-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-(2-cyclopropyl-ethyl)-piperazine-1-carboxylic acid 3-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclobutylmethyl-piperazine-1-carboxylic acid 3-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclobutylmethyl-piperazine-1-carboxylic acid 3-fluorine-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclobutylmethyl-piperazine-1-carboxylic acid 2-fluorine-4-(3-methyl-4,10-dihudro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclopropylmethyl-piperazine-1-carboxylic acid 2-fluorine-4-(3-methyl-4,10-dihydro-3H-2,3,4;9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclobutylmethyl-piperazine-1-carboxylic acid 4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclopropylmethyl-piperazine-1-carboxylic acid 3-ethyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclobutylmethyl-piperazine-1-carboxylic acid 2-chlorine-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide; 4-cyclopropylmethyl-piperazine-1-carboxylic acid 2-chlorine-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide and 4-cyclobutylmethyl-piperazine-1-carboxylic acid 3-methoxy-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraazabenzo[f]azulene-9-carbonyl)-benzylamide. Invention also relates to pharmaceutical composition and to application of compounds of general formula 1.

EFFECT: obtaining novel biologically active compounds and based on them pharmaceutical composition, possessing antagonistic activity with respect to vasopressin receptors.

60 cl, 153 ex

Similar patents RU2340617C2

Title	Year	Author	Number
VASOPRESSIN V RECEPTOR ANTAGONISTS	2005	Andzhej Roman Batt Bakster Ehndrju Dzhon Khini Selin Stokli Martin Li Brajan Ro Majkl Khadson Piter Khehndi Rejchel	RU2370497C2
HETEROCYCLIC CONDENSED COMPOUNDS USEFUL AS ANTIDIURETIC AGENTS	2005	Pitt Gari Robert Uil'Jam	RU2359969C2
SUBSTITUTED 3-OXO-1,2,3,4-TETRAHYDROXINOXALINES, PHARMACEUTICAL COMPOSITIONS (VARIANTS), METHODS FOR PRODUCTION AND USES THEREOF	2003	Ivashchenko A.V. Kobak V.V. Il'In A.P. Kravchenko D.V. Tkachenko S.E. Okun' Il'Ja Matusovich	RU2251546C1
SUBSTITUTED DERIVATIVES OF 1-OXA-2,8-DIAZASPIRO[4,5]DEC-2-ENE, METHOD FOR PRODUCTION THEREOF AND DRUG HAVING ANALGESIC ACTION	2002	Bushmann Khel'Mut Genrikh Ehngl'Berger Verner Gjunter Germann Tino Khennis Khagen-Genrikh Maul' Korinna Zundermann Bernd Kholents Jerg	RU2296128C2
ARYLCYCLOHEXYL ESTERS OF DIHYDROTETRAAZABENZOAZULENES FOR USE AS VASOPRESSIN V1A RECEPTOR ANTAGONISTS	2009	Shnajder Patrik	RU2507205C2
ALKYL CYCLOHEXYL ESTERS OF DIHYDROTETRAAZABENZOAZULENES	2009	Shnajder Patrik	RU2510397C2
SPIRO-5,6-DIHYDRO-4H-2,3,5,10B-TETRA-AZA-BENZO[E]AZULENES	2009	Bissants Katerina Getshi Ehrvin Jakob-Roehtne Roland Maskiadri Rafaehllo Pinar Ehmmanjuehl' Ratni Khasan Rodzhers-Ehvans Mark Shnajder Patrik	RU2514429C2
ARYL-CYCLOHEXYL-TETRAAZABENZO[e]AZULENES	2011	Dolente Kozimo Shnider Patrik	RU2566759C2
1,3-DISUBSTITUTED 4-METHYL-1H-PYRROL-2-CARBOXAMIDES AND USE THEREOF FOR PREPARING DRUGS	2007	Oberbersh Shtefan Zundermann Bernd Zundermann Korinna Bejsterveld Ehdvard Khennis Khagen-Genrikh	RU2463294C2
POLYCYCLIC AGENTS FOR TREATING RESPIRATORY SYNCYTIAL VIRAL INFECTIONS	2004	Bond Sajlas Sanford Vanessa Ann Lambert Dzhon Nikolas Lim Chin Ju. Mitchell Dzheffri Piter Drehffan Ehlister Dzhordzh Nirn Roland Genri	RU2422444C2

RU 2 340 617 C2

Authors

Khadson Piter

Batt Andzhej Roman

Khini Selin Margerit Sajmon

Bakster Ehndrju Dzhon

Rou Majkl Brajan

Robson Piter Ehndrju

Dates

2008-12-10—Published

2004-02-12—Filed