ALKYL CYCLOHEXYL ESTERS OF DIHYDROTETRAAZABENZOAZULENES Russian patent published in 2014 - IPC C07D487/04 A61K31/5517 A61P15/00 A61P9/00 A61P25/00 

FIELD: chemistry.

SUBSTANCE: described are novel alkyl cyclohexyl esters of 5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene derivatives of formula I where R is C_1-8-alkyl, optionally substituted with a halogen, hydroxy or C_1-12-alkoxy, CF₃, C_3-7-cycloalkyl, a 4-6-member heterocycloalkyl containing one O, R is H, C_1-8-alkyl, optionally substituted with OH, -(CH₂)_q-R^a, where R^a is a 6-member heteroaryl containing one N, -C(O)-C_1-8-alkyl, where the alkyl is optionally substituted with OH, -C(O)(CH₂)_qOC(O)-C_1-8-alkyl, -C(O)O-C_1-8-alkyl, -S(O)₂-C_1-8-alkyl or -S(O)₂NRⁱRⁱⁱ, where Rⁱ and Rⁱⁱ are identical and denote C_1-8-alkyl, q=1, R³ is Cl or F, and a pharmaceutical composition containing said compounds.

EFFECT: compounds are V1a receptor antagonists and can be used in medicine.

15 cl, 69 ex, 3 tbl