METHOD OF PITUITARY THYROID SYSTEM DESYNCHRONOSIS DIAGNOSTICS IN STEROID-DEPENDENT PATIENTS SUFFERING FROM SEVERE BRONCHIAL ASTHMA UNDERWENT LONG-TERM MAINTAINING DOSES OF SYSTEMIC GLUCOCORTICOIDS Russian patent published in 2008 - IPC G01N33/78 

FIELD: medicine.

SUBSTANCE: method is implemented as follows. Blood is tested for concentration of TSH, hormones T₃, T₄ with radioimmunoassay. Received data are processed. Graphical circadian rhythm curve is plotted for each hormone and used to evaluate time of individual acrophase and bathyphase. Acrophase indicators (confidence interval) of TSH development biorhythm 9 h 55 min (confidence interval within 5 h 20 min to 14 h 29 min), T₃ development biorhythm 15 h 19 min (confidence interval within 8 h 14 min to 22 h 23 min), T₄ development biorhythm 17 h 22 min (confidence interval within 9 h 20 min to 25 (01) h 23 min), and bathyphase indicators of TSH secretion circadian rhythm within 21 h to 22 h, T₃ secretion circadian rhythm within 2 h to 4 h, T₄ secretion circadian rhythm within 5 h to 6 h show diagnosed stable desynchronosis of pituitary thyroid system.

EFFECT: prescription of individual chronotherapy regimen.

9 dwg, 2 ex