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2 753 000

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(51)

IPC

A61B5/00(2006-01-01)

G01N33/74(2006-01-01)

G09B23/28(2006-01-01)

(21) (22)

Application

2020136013, 2020-11-02

(24)

Start date

2020-11-02

(22)

Actual filing date

2020-11-02

(45)

Published

2021-08-11

(72)

Inventor

Zlobina Olga VyacheslavovnaIvanov Aleksej NikolaevichBugaeva Irina OlegovnaMoskvina Aleksandra OlegovnaRomanova Vera Mikhajlovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Meditsinskij Universitet Imeni V.I. Razumovskogo" Ministerstva Zdravookhraneniya Rossijskoj Federatsii Vo Saratovskij Gmu Im. V.I. Razumovskogo Minzdrava Rossii)

METHOD FOR ASSESSING CENTRAL DESYNCHRONIZATION OF ORGANISM IN RATS Russian patent published in 2021 - IPC A61B5/00 G01N33/74 G09B23/28

Abstract RU 2753000 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to experimental medicine, chronobiology, pathophysiology, veterinary medicine, and can be used to assess the central desynchronization of the body in rats. Serum concentrations of melatonin, corticotropin and β-endorphin are studied. The desynchronization index k is calculated, defined as the ratio of the concentration of corticotropin to the sum of the concentrations of melatonin and β-endorphin. At k>0.15 the development of desynchronosis in the rat, affecting the central regulatory mechanisms, is noted.

EFFECT: invention provides an opportunity to improve the quality and prognostic value of biochemical assessment of the adverse effects of light desynchronosis in the study of biological rhythms of the body in rats due to a comprehensive assessment of the activity of the pineal gland and the hypothalamic-pituitary system.

1 cl, 1 tbl, 3 ex

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RU 2 753 000 C1

Authors

Zlobina Olga Vyacheslavovna

Ivanov Aleksej Nikolaevich

Bugaeva Irina Olegovna

Moskvina Aleksandra Olegovna

Romanova Vera Mikhajlovna

Dates

2021-08-11—Published

2020-11-02—Filed