DIAGNOSTIC TECHNIQUE FOR DESYNCHRONOSIS OF HYPOPHYSIAL THYROID SYSTEM IN PATIENTS WITH SEVERE BRONCHIAL ASTHMA, PREVIOUSLY NOT TAKING GLUCOCORTICOID THERAPY Russian patent published in 2010 - IPC G01N33/74 

FIELD: medicine.

SUBSTANCE: diagnostic technique for desynchronosis of hypophysial thyroid system in the patients with severe bronchial asthma refers to medicine. Substance consists that blood of the patients is radioimmunoassayed for concentration of TSH, T₃, T₄ hormones. The obtained data are processed to draw a graphic curve of circadian rhythm for each hormone that provides a basis to determine individual acrophase and batiphase time. The acrophase (confidence interval) TSH development biorhythm 9 h 11 min (confidential interval 4 h 57 min to 13 h 26 min), T₃ hormone - 15 h 01 min (confidential interval 8 h 05 min to 21 h 57 min) T₄ hormone - 16 h 34 min (confidential interval 8 h 55 min to 24 h 13 min), and batiphase of circadian TSH secretion rhythm 21 h to 22 h, T₃ - 2 h to 4 h, T₄ 4 h to 5 h ensure to diagnose apparent desynchronosis of hypophysial thyroid system.

EFFECT: application of the method allows to detect desynchronosis of hypophysial thyroid system in the patients with severe bronchial asthma, previously not taking glucocorticoid therapy and thereby prescribing an individual regimen of chronotherapy, enabling monitoring during treatment for a complex estimate of clinical effectiveness, reducing frequency of collateral actions, ensuring earlier remission and reducing time of staying in hospital.

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