SUBSTITUTED ARYLALKANE ACID DERIVATIVES AS PAN AGONISTS RAPP WITH HIGH ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY Russian patent published in 2008 - IPC C07D209/82 C07D279/22 C07D265/38 C07D471/04 A61K31/403 A61K31/538 A61K31/5415 A61K31/55 A61P3/10 A61P3/04 

FIELD: chemistry.

SUBSTANCE: described is obtaining and pharmaceutical application of substituted derivatives of arylalkane acid of formula I , where ring A, ring B, R¹, R², R³, R⁴, R⁵, X, Alk¹, Alk², Ar¹ and Ar² are such as determined in said description. Said compounds, as selective agonists activating (RAPPs) receptors, activated by peroximal proliferator, in particular, RXRs/RAPPs-alfa, RXRs/RAPPs-gamma and RXRs/RAPPs-delta heterodimers, are applied in treatment and/or prevention of type 2 diabetes and connected with it metabolic syndrome, such as hypertension, obesity, insulin-resistence, hyperlipidemia, hyperglycemia, hyperolesterinemia, artheriaslerosis, coronary artery disease, and other cardio-vascular disorders, and possess improved profile of side effects, connected with common RAPPs-gamma agonists.

EFFECT: obtaining compunds, which possess improved profile of side effects, connected with common RAPPs-gamma agonists.

22 cl, 38 ex, 2 tbl, 10 dwg