PYRIMIDINE DERIVATIVES AND USE THEREOF IN TREATING RESPIRATORY DISEASES, SUCH AS COPD Russian patent published in 2016 - IPC C07D487/04 A61K31/519 A61P11/00 A61P11/12 A61P1/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a novel compound of formula (I) or a pharmaceutically acceptable salt thereof, having inhibitory activity on human neutrophil elastase (HNE). In formula (I) , A is C-R¹; R¹ and R² are hydrogen; R⁴ is hydrogen; R³ and R⁵ are independently selected from hydrogen and C₁-C₆-alkyl, which can be substituted with halogen; R⁶ is selected from -COOH, -COOR^A, -CONH₂, -CONHR^A and -CONR^AR^B, where R^A and R^B independently represent (C₁-C₆)alkyl; -X¹-X²- is -CR¹⁵=N- or -NR¹⁹-CO-; R¹⁵ and R¹⁹, each independently, represent a radical of formula -[Y]_m-[Alk¹]_p-[Alk²]_q-Z, where Y is -(C=O)NR^E- or -NR^E(C=O)-, where R^E is hydrogen or C₁-C₆-alkyl; m, p, q are independently equal to 0 or 1; provided that m, p and q are not simultaneously equal to 0, when -X¹-X²- is -CR¹⁵=N-; Alk¹ and Alk², each independently, denote C₁-C₆-alkylene radical; Z is -N(R^A)(R^B), where R^A and R^B independently represent hydrogen or C₁-C₆-alkyl group.

EFFECT: compounds can be used for treating a disease or condition, which is a chronic obstructive pulmonary disease (COPD), chronic bronchitis, pulmonary fibrosis, pneumonia, acute respiratory distress syndrome (ARDS), emphysema, emphysema caused by smoking, or mucoviscidosis, asthma, rhinitis, psoriasis, atopic dermatitis, non-atopic dermatitis, Crohn's disease, ulcerative colitis or irritable bowel disease.

14 cl, 4 ex