CONDENSING DICYCLIC NITROGEN CONTAINING HETEROCYCLES, WHICH HAVE DGAT INHIBITING ACTION Russian patent published in 2008 - IPC C07D491/52 C07D487/04 C07D513/04 A61K31/519 A61K31/436 A61P3/10 A61P9/10 A61P3/04 A61P3/06 A61P1/16 

FIELD: chemistry; pharmacology.

SUBSTANCE: present invention relates to new condensed dicyclic nitrogen-containing heterocycles with the general formula (I), their pharmaceutically accepted salts and stereoisomers, possessing DGAT inhibiting action. In the compound of formula (I): , X is selected from a group, which consists of C(R¹) and N; Y is selected from a group, which consists of C(R¹), C(R²)(R²), N and N(R²); Z is selected from a group, which consists of O; W¹ is selected from cyclo(C₃-C₆)alkyl, aryl and 5- or 6-member heteroaryl, containing 1-2 heteroatoms, selected from a group, which comprises of nitrogen and sulphur, W² selected from cyclo(C₃-C₈)alkyl, (C₅-C₆)heterocycloalkyl, containing 1 or 2 heteroatoms, selected from groups, consisting of nitrogen or oxygen, benzol and 5-or 6-member heteroaryl, containing 1-2 nitrogen atoms as heteroatoms, L¹ is the link; L² is selected from a group consisting of links, 0, (C₁-C₄)alkylene and (C₁-C₄)oxyalkylene; m denotes 0 or 1; its not a must that when m denotes 1 and L² denotes a link, the substitute for W² can be integrated with the substitute for W¹ forming a 5-or 6-member ring, condensed with c W¹ forming a spiro-system or condensed with W², where specified ring could be saturated or unsaturated and has 0 or 1 atom O, as a member of the ring R¹ is H; R² is H; R³ and R⁴ are independently selected from groups consisting of H and (C₁-C₈) alkyl; optionally, R³ and R⁴ can together form 3-, 4-, 5- or 6-member spirorings, R⁵ and R⁶ are independently H; optionally, when Y includes the group R¹ or R², R⁵ or R⁶ can be joined with R¹ and R² forming a 5- or 6-member condensate ring, containing a nitrogen atom, to which R⁵ or R⁶ are joined, and optionally containing an oxo-group; R⁷ is selected from a group, composed of H, (C₁-C₈) alkyl, halogen(C₁-C₄)alkyl, 0R^a and NR^aR^b ; R^a selected from groups composed of H and (C₁-C₈)alkyl; and R^b selected from groups consisting of H and (C₁-C₈)alkyl; a dotted line indicates a possible bond. The invention also relates to pharmaceutical compositions and applications of the compounds.

EFFECT: obtaining compounds which can be used for getting medicinal agents to treat or prevent diseases or a mediated action state of DGAT, such as obesity, diabetes, syndrome X, resistance of insulin, hyperglycemia, hyperinsulinemia, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, disease of non-alcoholic fatty infiltration of the liver, atherosclerosis, arteriosclerosis, coronary artery disease and myocardial infarction.

33 cl, 17 dwg, 11 tbl, 391 ex