5-MEMBERED HETEROCYCLIC COMPOUND AND ITS APPLICATION FOR MEDICINAL PURPOSES Russian patent published in 2014 - IPC C07D207/34 C07D231/14 C07D231/16 C07D231/20 C07D231/38 C07D231/40 C07D401/04 C07D401/12 C07D401/14 C07D403/04 C07D405/04 C07D405/06 C07D405/10 C07D405/14 C07D409/04 C07D409/12 C07D409/14 C07D413/12 C07D417/04 A61K31/402 A61K31/404 A61K31/415 A61K31/4155 A61K31/427 A61K31/4439 A61K31/454 A61K31/5377 A61P13/02 A61P19/06 

FIELD: chemistry.

SUBSTANCE: invention relates to 5-membered heterocyclic compounds of general formula (I), their prodrugs or pharmaceutically acceptable salts, which possess xanthine oxidase inhibiting activity. In formula (I) T represents nitro, cyano or trifluoromethyl; J represents phenyl or heteroaryl ring, where heteroaryl represents 6-membered aromatic heterocyclic group, which has one heteroatom, selected from nitrogen, or 5-membered aromatic heterocyclic group, which has one heteroatom, selected from oxygen; Q represents carboxy, lower alkoxycarbonyl, carbomoyl or 5-tetrasolyl; X¹ and X² independently represent CR² or N, on condition that both of X¹ and X² do not simultaneously represent N and, when two R² are present, these R² are not obligatorily similar or different from each other; R² represents hydrogen atom or lower alkyl; Y represents hydrogen atom, hydroxy, amino, halogen atom, perfluoro(lower alkyl), lower alkyl, lower alkoxy, optionally substituted with lower alkoxy; nitro, (lower alkyl)carbonylamino or (lower alkyl) sulfonylamino; R¹ represents perfluoro(lower alkyl), -A^A, -A-D-L-M or -A-D-E-G-L-M (values A^A, A, D, E, G, L, M are given in i.1 of the invention formula).

EFFECT: invention relates to xanthine oxidase inhibitor and pharmaceutical composition, which contain formula (I) compound.

27 cl, 94 tbl, 553 ex