CYCLOALKYL COMPOUNDS - INHIBITORS OF POTASSIUM CHANNELS FUNCTION Russian patent published in 2009 - IPC C07C233/59 C07C233/60 C07C279/28 C07C307/08 C07C311/16 C07D261/08 C07D213/82 C07D271/06 C07D409/12 C07D413/12 A61K31/155 A61K31/165 A61K31/415 A61K31/4427 A61K31/4245 

FIELD: chemistry.

SUBSTANCE: compound of formula I , its diastereomers or salts, where dot line represents optional double bond, m and p independently stand for 0, 1, 2 or 3; R¹ stands for H, -N(R⁸)-C(O)-NR⁶R⁷, -N(R⁸)-S(O)₂-NR⁶R⁷, -N(R⁸)-C(O)-N(R^8a)-S(O)₂-NR⁶R⁷, etc.; R^1a stands for H or group OH; or R¹ or R^1a together form oxo; or R¹ and R^1a together with carbon atom, to which they are bound, form optionally substituted oxo spiro-condensed heterocyclic group, representing fully saturated 5-member monocyclic group, containing 2 nitrogen atoms; R² stands for heteroaryl, (heteroary)alkyl, representing 5-6-member aromatic ring, contaning 1 nitrogen atom and/or 1 atom of oxygen and/or sulphur, and optionally condensed with aryl ring; aryl, (aryl)alkyl, alkyl, alkenyl or cycloalkyl, representing partly or fully saturated C₃-C₆ monocyclic structure, any of which can be optionally, independently, substituted with one or more groups T¹, T² or T³; J stands for bond, C_1-4 alkylene, R³ stands for -R⁵, -C(Z¹)-R⁵, -N(R^8a1)-C(Z¹)-R⁵, -N(R^8a1)-C(Z¹)-O-R⁵, -N(R^8a1)-S(O)₂-R⁵; R⁴ stands for alkyl, halogenalkyl, cycloalkyl, aryl, which can be optionally condensed with heteroaryl 6-member ring, containing 1-2 heteroatoms, selected from group SO₂, N, etc.; R⁵ stands for -NR^6aR^7a or heteroaryl, (heteroaryl)alkyl, representing 5-6-member aromatic ring, which contains 1-3 nitrogen atoms and/or 1 or 2 atoms of oxygen or sulphur, optionally condensed with heteroaryl ring, representing 6-member aromatic ring, containing 1 nitrogen atom, etc.; R^6a, R^7a independently represent H, alkyl, aryl, (aryl)alkyl, heteroaryl, representing 5-6-member aromatic ring, which contains 1-2 nitrogen atoms, optionally condensed with aryl or heteroaryl ring, representing 6-member aromatic ring with 1 nitrogen atom; any of which can be optionally, independently, substituted with one or more groups T^1c, T^2c or T^3c; R⁶, R⁷, R⁸, R^8a, R^8a1 R^8a2, and R⁹, independently, represent H, alkyl, hydroxy, alkoxy, (hydroxy)alkyl, (alkoxy)alkyl, (cyano)alkyl, (alkenyl)alkyl, -NR¹²R¹³, cycloalkyl, (cycloalkyl)alkyl, optionally condensed with aryl; aryl, (aryl)alkyl, heteroaryl, (heteroaryl)alkyl, etc.; R¹⁰, R^10a, R¹¹ and R^11a, independently, represent H, alkyl, aryl, (aryl)alkyl, , hydroxy, (hydroxy)alkyl; heteroaryl, (heteroaryl)alkyl, representing 5-member aromatic ring, which contains 2 nitrogen atoms, or R¹¹ and R^11a can together form oxogroup, or R^10a can together with R^11a form bond, or R¹⁰ can together with R⁹ form saturated 3-4-member cycle; R¹² and R¹³, independently, represent H, alkyl; W represents =NR^8a2, =N- CO₂R^8a2, =N- CN; X represents C(=O), C=N-CN; Z¹represents =O, or =N-CN; R^X represents one optional substituent, bound with any suitable carbon atom in cycle, independently selected from T^1g, T^2g or T^3g. Compounds of formula I are applied for manufacturing medication for treatment of I_Kur-mediated disorders.

EFFECT: cycloalkyl compounds, useful as inhibitors of potassium channels function.

13 cl, 694 ex, 1 tbl