ANTHELMINTIC COMPOUNDS CONTAINING AZAINDOLE STRUCTURE Russian patent published in 2025 - IPC C07D471/04 A61P33/10 A01N43/90 

Abstract RU 2833563 C1

FIELD: chemistry.

SUBSTANCE: present invention relates to novel anthelmintic compounds, specifically to a compound of formula (I) or a stereoisomer thereof, a physiologically acceptable salt and mixtures thereof. In formula (I), the values of radicals are as follows: R1 is hydrogen, R7 is independently selected from the group consisting of 6-member heterocyclyl comprising two heteroatoms O and N, hydroxy, NR8R9, R8 and R9 are independently selected from the group consisting of hydrogen, C1-6-alkyl, R13 is hydrogen, R14 is hydrogen, or R13 and R14 together with the atoms to which they are attached form a non-aromatic ring containing 5 or 6 carbon atoms, where ring containing 5 or 6 carbon atoms is optionally substituted with one or more substitutes C1-3-alkyl or =O, and/or where one of the ring-forming carbon atoms is optionally substituted with -O-, or R13 and R14 together with the atoms to which they are attached form an aromatic ring containing 5 or 6 carbon atoms, where ring containing 5 or 6 carbon atoms is optionally substituted with one or more C1-3alkyl substitutes, R15 independently denotes hydrogen, R16 independently denotes hydrogen, R17 independently denotes hydrogen, R18 independently denotes hydrogen, R19 is independently selected from the group consisting of C6-10-aryl, where C6-10-aryl is optionally substituted with one or more substituents independently selected from the group consisting of C1-6-alkyl, C1-6-alkoxy, halogen, NR20R21, R20 and R21 are independently selected from the group consisting of hydrogen, C1-6-alkyl, R25 is hydrogen. Also disclosed is a method of producing said compound and a veterinary composition.

EFFECT: invention provides novel anthelmintic compounds which can be used to treat infections in mammals caused by parasitic helminths, such as Dirofilaria, particularly Dirofilaria immitis.

15 cl, 2 tbl, 3 ex

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RU 2 833 563 C1

Authors

Berger, Michael

Linder, Michael

Schneider, Carolin

Tanzler, Janina

Sondern, Ulrich

Dates

2025-01-24Published

2020-12-17Filed