ANTHELMINTIC COMPOUNDS CONTAINING AZAINDOLE STRUCTURE Russian patent published in 2025 - IPC C07D471/04 A61P33/10 A01N43/90 

FIELD: chemistry.

SUBSTANCE: present invention relates to novel anthelmintic compounds, specifically to a compound of formula (I) or a stereoisomer thereof, a physiologically acceptable salt and mixtures thereof. In formula (I), the values of radicals are as follows: R¹ is hydrogen, R⁷ is independently selected from the group consisting of 6-member heterocyclyl comprising two heteroatoms O and N, hydroxy, NR⁸R⁹, R⁸ and R⁹ are independently selected from the group consisting of hydrogen, C_1-6-alkyl, R¹³ is hydrogen, R¹⁴ is hydrogen, or R¹³ and R¹⁴ together with the atoms to which they are attached form a non-aromatic ring containing 5 or 6 carbon atoms, where ring containing 5 or 6 carbon atoms is optionally substituted with one or more substitutes C_1-3-alkyl or =O, and/or where one of the ring-forming carbon atoms is optionally substituted with -O-, or R¹³ and R¹⁴ together with the atoms to which they are attached form an aromatic ring containing 5 or 6 carbon atoms, where ring containing 5 or 6 carbon atoms is optionally substituted with one or more C_1-3alkyl substitutes, R¹⁵ independently denotes hydrogen, R¹⁶ independently denotes hydrogen, R¹⁷ independently denotes hydrogen, R¹⁸ independently denotes hydrogen, R¹⁹ is independently selected from the group consisting of C_6-10-aryl, where C_6-10-aryl is optionally substituted with one or more substituents independently selected from the group consisting of C_1-6-alkyl, C_1-6-alkoxy, halogen, NR²⁰R²¹, R²⁰ and R²¹ are independently selected from the group consisting of hydrogen, C_1-6-alkyl, R²⁵ is hydrogen. Also disclosed is a method of producing said compound and a veterinary composition.

EFFECT: invention provides novel anthelmintic compounds which can be used to treat infections in mammals caused by parasitic helminths, such as Dirofilaria, particularly Dirofilaria immitis.

15 cl, 2 tbl, 3 ex