BENZYLPYRIDAZINONES AS INHIBITORS OF REVERSE TRANSCRIPTASE Russian patent published in 2009 - IPC C07D237/14 C07D237/22 C07D405/06 C07D401/12 C07D309/06 A61K31/50 A61K31/501 A61P31/18 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention concerns bonds, applicable for treatment of diseases mediated by the HIV virus, formula I where X¹ is chosen from R⁵O, R⁵S(O)_n, R⁵CH₂, R⁵CH₂O, R⁵CH₂S(O)_n, R⁵OCH₂ and R⁵S(O)_nCH₂; R¹ and R² are chosen from H, NH₂, alkyl, haloalkyl, cycloalkyl, alkoxy, alkylthio, halogen, alkylamino, dialkylamino, nitro and cyano; or in common form-CH=CH-CH=CH- or five-term heterocycle with the heteroatom chosen from O and S; R³ is chosen from H, halogen, nitro and cyano; R⁴ is chosen from H, NH₂, alkyl, haloalkyl, cycloalkyl, alkoxy, alkylthio, halogen, alkylamino, dialkylamino, nitro and cyano; R⁵ the pyridine-N-oxide, indole, chinoline, chinoline-N-oxide is chosen from alkyl, cycloalkyl and unessentially replaced phenyl, naphthyl, pyridinil; R⁷ and R⁸ are chosen from H, NH₂, an alkylamin, dialkylamine and unessentially substituted C₁-C₆alkyl; n is chosen from 0, 1, 2.

EFFECT: obtaining of new inhibitors by reverse transcriptase.

2 cl, 46 ex, 3 tbl