FIELD: chemistry.
SUBSTANCE: invention relates to new pyrimidine of the general formula (I), which possess properties of the inhibitor of CDK-kinase. In the general formula (I) 
R1 designates hydrogen, halogen, C1-C6alkyl, R2 designates C1-C10alkyl, C1-C10alkenyl, or C3-C10cycloalkyl which can be mono-, bi- or tricyclic or denotes one- or polysubstituted by identical or different substitutes from the number of hydroxy-group, halogen, C1-C6alkoxygroup, C1-C6kalkylthiogroup, -NH-(CH2)n-C3-C10cycloalkyl, C3-C10 cycloalkyl, C1-C6hydroxyalkyl, C1-C6alkoxy-C1-C6alkyl, C1-C6alkoxy-C1-C6alkoxy-C1-C6alkyl, -NHC1-C6alkyl, -N(C1-C6alkyl)2, C1-C6alkanoil, -CONR3R4, -COR5, C1-C6alkylOAc, where Ac indicates C1-C4alkylCO-group, carboxygroups, phenyl, 5-6-member heteroaryl, containing 1-2-heteroatom in the ring, selected from nitrogen, -(CH2)n- phenyl, -(CH2)n-5-6-member heteroaryl containing 1-2-heteroatom in a ring, selected from nitrogen, phenyl-(CH2)n-R5, -(CH2)nPO3(R5)2 and -R6 and -NR3R4C1-C10alkyl, or C3-C10cycloalkyl, in this case phenyl, C3-C10 cycloalkyl, heteroaryl, -(CH2)n-phenyl and -(CH2)n heteroaryl can be one or polysubstituted by identical or different substitutes from halogens, hydroxygroup, C1-C6alkyl, C1-C6alkoxygroup, benzoxy-group and -CF3 groups, and ring of C3-C10 cycloalkyl and C1-C10alkyl can be separated by one or several nitrogen atoms, oxygen and/or sulfur and/or the said ring can be interrupted by one or two groups of =C=O or R2 designates the group 
X designates oxygen or group-NH-, and one of A and B independently indicates hydrogen, and the other indicates hydrogen, hydroxygroup, C1-C3alkyl, C1-C6alkyoxy,group SR7, SO2R7, CO(OH)R7, CR7(OH)R7, C1-C6alkyl-P(O)OR3OR4, COR7 or A and B together form C3-6-cycloalkyl ring which does not necessarily have to be interrupted by 1-3 atoms of nitrogen, oxygen and/or sulfur and/or can be interrupted by =C=O or =SO2 groups, and/or does not necessarily have to contain one or several double bonds, X designates oxygen or group-NH-, either one from A and B independently indicates hydrogen, and the other indicates hydrogen, hydroxygroup, C1-C3alkyl, C1-C6alkyoxy,group SR7, SO2R7, CO(OH)R7, CR7(OH)R7, C1-C6alkyl-P(O)OR3OR4, COR7 or A and B together form C3-6-cycloalkyl ring which does not necessarily have to be interrupted by 1-3 atoms of nitrogen, oxygen and/or sulfur and/or can be interrupted by =C=O or =SO2 groups, and/or does not necessarily have to contain one or several double bonds, values of R3 -R10 are specified in the formula of the invention.
EFFECT: connections can be used for the treatment of cancer, autoimmune diseases caused by chemotherapeutic means of alopecia and inflammations of mucous membrane, cardiovascular diseases, infectious diseases, chronic neurodegenerative and viral infections.
13 cl, 1 tbl, 540 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING CYCLIC DIKETONES | 2005 |
|
RU2384562C2 |
| METHOD FOR PREPARING CYCLIC DIKETONES | 2003 |
|
RU2316544C2 |
| SUBSTITUTED DERIVATIVES OF 1-AMINOBUTANE-3-OL, METHOD FOR THEIR PREPARING AND MEDICINAL AGENT | 2001 |
|
RU2288219C2 |
| THIAZOLYL DIHYDROQUINAZOLINES | 2007 |
|
RU2430923C2 |
| INDAZOL DERIVATIVES AS CRF ANTAGONISTS | 2003 |
|
RU2341518C2 |
| CONDENSED PIRIMIDINE DERIVATIVE AND PHARMACEUTICS WITH CRF RELATED ACTIVITY | 2004 |
|
RU2328497C2 |
| DERIVATIVES OF HYDROXAMIC ACID | 1997 |
|
RU2196131C2 |
| FUNGICIDAL COMPOSITIONS | 2012 |
|
RU2592554C2 |
| SUBSTITUTED PYRIDINES AS HERBICIDES | 2001 |
|
RU2326866C2 |
| 2,4-DI(AMINOPHENYL)PYRIMIDINES AS PLK-KINASE INHIBITORS | 2005 |
|
RU2404979C2 |
