FIELD: chemistry, pharmaceutics.
SUBSTANCE: invention relates to novel compounds of general formula I , in which stands for thiophendiyl, phenylene or pyridindiyl; R1 represents alkyl, alkenyl, alkinyl, which optionally contain one or several substitutes, selected from group including halogen, cyano-, nitro- amino group, -NH-alkyl and N(alkyl)2; or -CH2-(O-CH2-CH2-)mO-alkyl; -(CH2)n-O-alkyl; -(CH2)n-C(O)-NH-alkyl; -(CH2)n-NH-C(O)-alkyl; -(CH2)n-C(O)alkyl; -(CH2)n-C(O)-O-alkyl; or -(CH2)n-O-C(O)-alkyl; or group -NR3R4, in which R3 and R4 independently represent hydrogen; alkyl, alkenyl or alkinyl, which optionally contain one or several substitutes, selected from group including halogen, cyano-, nitro- amino group, -NH-alkyl and N(alkyl) 2; or -CH2-(O-CH2-CH2-)mO-alkyl; -(CH2)n-(O)-alkyl; -(CH2)n-C(O)-NH-alkyl; -(CH2)n-NH-C(O)-alkyl; -(CH2)n-C(O)alkyl; -(CH2)n-C(O)-O-alkyl; or -(CH2)n-O-C(O)-alkyl; n is 1-6; m is 1-4; and to its pharmaceutically acceptable salts. Invention also relates to medication.
EFFECT: obtaining novel biologically active compounds, intended for inhibition tumor cell proliferation.
25 cl, 6 ex
Title | Year | Author | Number |
---|---|---|---|
DERIVATIVES OF 2-(IMINOMETHYL)AMINOPHENYL, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE COMPOUNDS | 1998 |
|
RU2183211C2 |
NEW COMPOUNDS | 2001 |
|
RU2261245C2 |
PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | 2014 |
|
RU2663898C2 |
TETRAHYDROCARBAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION BASED ON SAID DERIVATIVES | 2005 |
|
RU2430088C2 |
DUAL-ACTING ANTIHYPERTENSIVE COMPOUNDS, METHODS FOR PREPARING THEM, BASED PHARMACEUTICAL COMPOSITIONS AND INTERMEDIATE COMPOUNDS | 2008 |
|
RU2476427C2 |
BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | 2012 |
|
RU2607045C2 |
DERIVATIVES OF HYDROXYMETHYLFURAZAN CARBOXYLIC ACID AND PHARMACEUTICAL PREPARATION | 1994 |
|
RU2134687C1 |
SUBSTITUTED DERIVATIVES OF 1-OXA-2,8-DIAZASPIRO[4,5]DEC-2-ENE, METHOD FOR PRODUCTION THEREOF AND DRUG HAVING ANALGESIC ACTION | 2002 |
|
RU2296128C2 |
CONDENSED AZEPINE DERIVATIVES AS ANTIDIUTETIC AGENTS | 2001 |
|
RU2269517C2 |
DERIVATIVES OF 8-METHOXY-[1,2,4]TRIAZOLO[1,5-a]PYRIDINE AND PHARMACEUTICAL PREPARATION BASED ON THEREOF | 2002 |
|
RU2297416C2 |
Authors
Dates
2009-01-27—Published
2003-12-09—Filed