DERIVATIVES OF (2-AMINOPHENYL)-AMIDE OF ARYLENECARBOXILIC ACID AS PHARMACEUTICAL PREPARATIONS Russian patent published in 2009 - IPC C07C233/77 C07D213/82 C07D333/38 C07D401/12 C07D409/12 A61K31/381 A61K31/165 A61K31/44 A61P35/00 

Abstract RU 2345061 C2

FIELD: chemistry, pharmaceutics.

SUBSTANCE: invention relates to novel compounds of general formula I , in which stands for thiophendiyl, phenylene or pyridindiyl; R1 represents alkyl, alkenyl, alkinyl, which optionally contain one or several substitutes, selected from group including halogen, cyano-, nitro- amino group, -NH-alkyl and N(alkyl)2; or -CH2-(O-CH2-CH2-)mO-alkyl; -(CH2)n-O-alkyl; -(CH2)n-C(O)-NH-alkyl; -(CH2)n-NH-C(O)-alkyl; -(CH2)n-C(O)alkyl; -(CH2)n-C(O)-O-alkyl; or -(CH2)n-O-C(O)-alkyl; or group -NR3R4, in which R3 and R4 independently represent hydrogen; alkyl, alkenyl or alkinyl, which optionally contain one or several substitutes, selected from group including halogen, cyano-, nitro- amino group, -NH-alkyl and N(alkyl) 2; or -CH2-(O-CH2-CH2-)mO-alkyl; -(CH2)n-(O)-alkyl; -(CH2)n-C(O)-NH-alkyl; -(CH2)n-NH-C(O)-alkyl; -(CH2)n-C(O)alkyl; -(CH2)n-C(O)-O-alkyl; or -(CH2)n-O-C(O)-alkyl; n is 1-6; m is 1-4; and to its pharmaceutically acceptable salts. Invention also relates to medication.

EFFECT: obtaining novel biologically active compounds, intended for inhibition tumor cell proliferation.

25 cl, 6 ex

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RU 2 345 061 C2

Authors

Fertig Georg

Kherting Frank

Kerner Mattias

Kubbis Manfred

Limberg Anja

Rajff Ul'Rike

Vajdner Mikhaehl'

Dates

2009-01-27Published

2003-12-09Filed