OXALIPLATIN WITH LOW CONTENT OF ACCOMPANYING ADMIXTURES AND METHOD OF OBTAINING IT Russian patent published in 2009 - IPC C07F15/00 

FIELD: chemistry.

SUBSTANCE: claimed invention relates to obtaining oxaliplatin used in tumor treatment, with low content of accompanying admixtures formed while obtaining it. Obtained is oxaliplatin with wt % content of admixtures of alkali metals not more than 0.01%, silver not more than 0.0005% and nitrates not more than 0.01%. Method of obtaining lies in the following: suspension of (SP-4-2)-dichloro-[(1R,2R)-1,2-cyclohexanediamine-N,N'] platinum (II) in water is processed with silver nitrate with molar ratio of complex compound to silver nitrate 1: ≤ 2, then, after removal of solid phase, obtained solution is processed with quaternary ammonium iodide of formula (R)₄NI, where R independently represents hydrogen atom, possibly substituted aliphatic or cycloaliphatic radical, on condition that, at least, one of symbols R does not represent hydrogen atom, isolated solid phase is removed and obtained solution is processed with oxalic acid, and separated oxaliplatin is isolated, washed with water and polar organic solvent or their mixture, dried, recrystallised from water, washed with water and polar organic solvent or their mixture and dried.

EFFECT: obtaining oxaliplatin with low content of admixtures, suitable for obtaining pharmaceutical preparation.

2 cl, 1 ex