METHOD OF PRODUCING POLYMERISED COORDINATION COMPLEXES OF PLATINUM Russian patent published in 2010 - IPC C08G81/00 C07F15/00 A61K31/282 A61P35/00 

Abstract RU 2382056 C2

FIELD: chemistry.

SUBSTANCE: method involves reaction in aqueous medium of a diaquaplatinum or bis(nitrato)platinum complex in a mixture with dihalogenoplatinum with a block-copolymer of formula (1): or (2):, where R1 represents hydrogen or C1-C12-alkyl, L1 and L2 - connecting groups, R3 - hydrogen, a protective group for amino groups, a hydrophobic or polymerised group, R4 represents hydroxy-, carboxy- or a hydrophobic group, R5 represents hydrogen, an alkali metal ion or a protective group for the carboxylic group, m=5-20000, n=10-60, under the condition that, R5 - hydrogen or an alkali metal ion constitutes 50% or more in n links.

EFFECT: obtaining a conjugate which does not contain silver ions, the solution of which has lower particle-size distribution.

17 cl, 11 dwg, 7 ex

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RU 2 382 056 C2

Authors

Kobajasi Katsutosi

Nagasaki Soko

Kataoka Kazunori

Tsutija Tieko

Dates

2010-02-20Published

2006-06-08Filed