METHOD OF PRODUCING BIOCOMPATIBLE COPOLYMERS OF N-VINYLPYROLIDONE WITH ALKYL ACRYLATES Russian patent published in 2009 - IPC C08F220/14 C08F220/18 C08F226/10 

FIELD: chemistry, pharmaceutics.

SUBSTANCE: invention relates to the methods of producing biocompatible pharmaceutical polymers. The proposed invention aims at developing the method of producing the copolymers of N-vinylpyrolidone with alkyl acrylates that will allow producing a high-uniform structure copolymers featuring molecular weight varying from 30 to 80 thousands not containing residual monomers and quickly dissolving in organic solvents. In compliance with this invention, for copolymerisation reaction of N-vinylpyrolidone with alkyl acrylates, it is proposed to prepare two solutions, i.e. an initiator in N-vinylpyrolidone (solution A) and that in the mix of N- vinylpyrolidone with alkyl acrylates (ratio varying from 5 : 95 to 15 : 85 wt %) (solution B) to carry out copolymerisation at temperatures from 70 to 90°C in the medium of organic solvent by gradually adding 4 to 8 various mixes of monomers resulted from mixing of aforesaid solutions A and B for 2 to 4 hours along with gradual changing of the N-vinylpyrolidone-to-acryl acrylate ratio from 95 : 5 to 10 : 90 wt % with the subsequent cooling down of reaction mix to 30 to 45°, followed by adding a precipitator till the formation of a coacervate solution of a copolymer and, with the subsequent decanting of the solvent-precipitator mix and drying of coacervate solution at residual pressure of 1 to 8 kPa at 65 to 85°C for 4 to 12 hours.

EFFECT: possibility of producing high-uniformity composition copolymers without toxic fractions and with molecular weight over 80 thousand, practically not containing residual monomers, and readily dissolving in ethanol.

1 cl, 4 tbl, 3 ex