FIELD: medicine.
SUBSTANCE: invention refers to method of production of lyophilised matrixe and, when restored, related injectable contrast medium containing liquid aqueous gas-filled microvoid suspension mainly phospholipid stabilised. Method includes preparation of emulsion based on aqueous environment, phospholipid and water-immiscible organic solvent. Then emulsion is dried with sublimation and restored to aqueous gas-filled microvoid suspension.
EFFECT: suspensions contain microvoids of relatively small diameter and narrow size distribution.
36 cl, 12 tbl, 16 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITION OF FOCUSED MICROVESICLES FILLED WITH GAS | 2015 |
|
RU2725808C2 |
| CONJUGATES OF PHOSPHOLIPIDS AND DIRECTION VECTOR MOLECULES | 2006 |
|
RU2433137C2 |
| PEGYLATED LIPID NANOPARTICLE WITH A BIOACTIVE LIPOPHILIC COMPOUND | 2016 |
|
RU2737893C2 |
| CAVITATION NUCLEUS FOR DRUG DELIVERY AND METHOD FOR DRUG DELIVERY USING SAME | 2016 |
|
RU2704823C2 |
| LYOPHILIZED COMPOSITION FOR GAS-FILLED MICROVESICLES | 2019 |
|
RU2803236C2 |
| METHOD FOR PREPARING SUBMICRON PACLITAXEL PARTICLES | 2004 |
|
RU2402313C2 |
| COATING FOR AN INTRALUMINAL DIVERGENT CATHETER, PROVIDING CONTACT DELIVERY OF MICRORESERVOIRS WITH A DRUG PREPARATION | 2015 |
|
RU2721655C2 |
| COATING FOR INTRALUMINAL EXPANDING CATHETER, PROVIDING CONTACT TRANSFER OF MICRORESERVOIRS WITH MEDICINAL PRODUCTS | 2019 |
|
RU2820776C2 |
| MICRON AND SUBMICRON-SIZE MICROBEADS WITH POLYMER WRAP AND METHOD OF MANUFACTURING THEREOF | 1991 |
|
RU2110991C1 |
| CONTRASTING SUBSTANCE, METHOD OF ITS PREPARING, METHOD OF HUMAN OR ANIMAL BODY IMAGE PRODUCING | 1994 |
|
RU2128520C1 |
