METHOD FOR PREPARING SUBMICRON PACLITAXEL PARTICLES Russian patent published in 2010 - IPC A61J3/02 A61K9/10 A61K9/14 A61K31/337 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to drugs. The method includes the following stages: (i) mixing of a first or second water-miscible solvent or with both the first water-miscible solvent, and the second water-miscible solvent and a first surface modifier containing phospholipid conjugated with water-soluble or hydrophilic polymer; (ii) mixing of the first or second water-miscible solvent or with both the first water-miscible solvent, and the second water-miscible solvent and a second surface modifier specified from the group consisting of anionic, cationic and non-ionic surface-active substances and surface-active biological modifiers; (iii) dissolution of paclitaxel or its derivatives in the first water-miscible solvent to prepare a solution; (iv) mixing of the solution and the second solvent to produce a preliminary suspension of particles; and (v) homogenisation of the preliminary suspension to make a suspension of deposited fine particles of mean effective size of grain approximately less than 1000 nm.

EFFECT: development of the method for preparing a pharmaceutical composition of submicron deposited particles of paclitaxel or its derivatives with solubility higher in the first water-miscible solvent than in the second solvent which is water.

34 cl, 20 dwg, 2 tbl, 21 ex