PIPERIDINE DERIVATIVES AS MODULATORS OF ACTIVITY OF CCR5 RECEPTOR, METHOD AND INTERMEDIATE COMPOUNDS FOR OBTAINING THEM, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Russian patent published in 2009 - IPC C07D401/06 C07D401/14 C07D405/14 C07D411/14 C07D413/14 C07D417/14 A61K31/4545 A61K31/496 A61P11/06 A61P17/00 A61P19/00 A61P29/00 

FIELD: chemistry.

SUBSTANCE: description is given of a piperidine derivative with general formula (I) , where L represents CH or N; M represents CH or N; under the condition that, L and M both do not represent CH; R¹ represents phenyl (possibly substituted with a halogen or C₁-₄alkyl), S(O)₂(C₁-₄alkyl), S(O)₂(C₁-₄fluroalkyl), S(O)₂phenyl (possibly substituted with CF₃ or OCF₃), benzyl, benzoyl (possibly substituted with a halogen) or C(O)NHphenyl (possibly substituted with a halogen); R² represents phenyl, possibly substituted with a halogen; R³ represents hydrogen or C₁-₄alkyl; R⁴ represents methyl or ethyl; R⁵ represents phenyl-NH, phenyl (C₁-₂alkyl), phenyl(C₁-C₂)alkyl-NH or pyridyl(C₁-₂alkyl). The phenyl can be substituted with a halogen, cyano, C₁-₄alkyl, C₁-₄alkoxy, S(O)_k(C₁-₄alkyl) or S(O)₂NR⁸R⁹; k is equal to 2; R⁸ and R⁹ represent hydrogen or its pharmaceutical salts. The compound is a modulator of the activity of the CCR5 receptor. Description is given of the method of obtaining the compound, where L represents N, and the pharmaceutical composition based on a compound with formula (I).

EFFECT: design of a method of obtaining a compound, where L represents N, and a pharmaceutical composition based a compound with formula (I).

7 cl, 7 tbl, 16 ex