EXPOSURE OF T-CELL RECEPTORS Russian patent published in 2009 - IPC C07K14/705 

Abstract RU 2346004 C2

FIELD: chemistry; biochemistry.

SUBSTANCE: present invention pertains to biotechnology. Description is given of a phage particle, exposing on its surface, T-cell receptor (TCR), which is a human scTCR. The exposed dTCR polypeptide pair or exposed scTCR polypeptide contains a series of α and β chains of extra-cellular constant lg of the native TCR domain. A disulphide bond joins amino acid residues of the given series of chains of the constant lg domain, where the given disulphide bond is between cysteic residues. Presented is a library of polypeptide pairs of mutated TCR or scTCR polypeptides, exposed on the described phage particle. Nucleic acid, which encodes the described phage particle, is also presented. A method of identifying TCRs is invented. The invention can be used for making various TCR libraries, for identification of high-affinity TCRs.

EFFECT: possibility of making various TCR libraries for identification of high-affinity TCRs.

17 cl, 25 ex, 63 dwg, 2 tbl

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RU 2 346 004 C2

Authors

Jakobsen Bent Karsten

Andersen Torben Bent

Molloj Piter Imon

Li Ji

Boulter Dzhonatan Majkl

Dates

2009-02-10Published

2003-10-30Filed