FIELD: biotechnology.
SUBSTANCE: invention can be used in medical practice. A bifunctional polypeptide structure is proposed that contains a peptide-major histocompatibility complex (pMNS) peptide-binding fragment, as well as a PD-1 agonist fragment.
EFFECT: inhibition of the PD-1 signaling pathway used in medicine, in particular in the prevention or treatment of various autoimmune diseases.
19 cl, 4 ex, 4 dwg
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