FIELD: medicine, pharmaceutics.
SUBSTANCE: invention concerns medicine, particularly immunotherapy. Anthracycline-antibody conjugate linked by linker containing twice substituted cyclohexane ring is claimed. Antibody included in conjugate is linked to CD74 antigene highly expressed in B cell lymphomas, melanomas and other tumours. Conjugate is internalised by target cells and expressed again on cell surface. Invention also claims method of obtaining indicated conjugate by anthracycline medium conjugation with linker and further with thiene-restored monoclonal antibody. Conjugate can be administered to patients when immunotherapy is required.
EFFECT: efficient method of obtaining anthracycline medicine obtainment.
11 cl, 8 ex, 5 dwg
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