FIELD: medicine.
SUBSTANCE: invention can be used for treating Trop-2-positive cancer in a patient. That is ensured by administering an antibody-drug conjugate (ADC) to a human patient with Trop-2-positive cancer. Patient has relapsed after treatment with a control point inhibitor or refractory treatment to a control point inhibitor. Said ADC contains SN-38 conjugated with linker fragment attached to antibody to Trop-2 or its antigen-binding fragment. Antibody is the hRS7 antibody. Said linker is CL2A. ADC has structure MAb-CL2A-SN-38.
EFFECT: invention provides treating the patients with Trop-2-positive cancer resistant to the control point inhibitors treatment.
21 cl, 11 tbl, 5 dwg, 18 ex
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