TERAHYDROCHINOLINE DERIVATIVES DEMONSTRATING ACTIVITY PREOTECTIVE AGAINST HIV Russian patent published in 2009 - IPC C07D401/14 C07D403/14 A61K31/497 A61K31/437 A61P31/18 

FIELD: chemistry.

SUBSTANCE: invention relates to tetrahydrochinoline derivatives represented by general formula , where t is equal 0, 1 or 2; each R independently represents H, alkyl, alkenyl or cycloalkyl; n is equal 0; R is selected from group, consisting of H, alkyl, halogenalkyl, cycloalkyl, alkenyl, alkinyl, -R^aAy, -R^aOR⁵ or group - R^acycloalkyl, and where R² is not substituted with amine or alkylamine; each R⁴ independently represents halogen; m is equal 0, 1 or 2; each R⁵ independently represents H, alkyl, alkenyl, alkinyl, cycloalkyl; p is equal 0 or 1; y represents -NR¹⁰-, -O-, -S-; X represents -N(R¹⁰)₂, -R^aN(R¹⁰)₂, -AyN(R¹⁰)₂, -R^aAyN(R¹⁰)₂, -AyR^aN(R¹⁰)₂, -R^aAyR^aN(R¹⁰)₂, -Het, -R^aHet, -HetN(R¹⁰)₂, -R^aHetN(R¹⁰)₂, -HetR^aN(R¹⁰)₂, -R^aHetR^aN(R¹⁰)₂, -HetR^aAy or -HetR^aHet; each R^a independently represents alkylene, possibly suibstituted with one or more than one alkyl or hydroxyl, cycloalkylene, possibly substituted with one or more than one alkyl or hydroxyl; each R¹⁰ independently represents H, alkyl, cycloalkyl, alkenyl, alkinyl, cycloalkenyl or -Ra-cycloalkyl; each Ay independently represents possibly substituted phenyl or naphtyl group; each Het independently represents possibly substituted 3-12-member mono- or polycyclic heterocyclyl group, containing as heteroatoms N, or 5-7-member possibly substituted heteroaryl group, containing as heteroatom N; or its pharmaceutically acceptable salts or ethers. Also described are methods of obtaining compounds of formula (I-G).

EFFECT: obtained are novel compounds, which demonstrate protective against HIV-infection effect on target-cells by means of specific binding with chemokine receptor and which influence binding of natural ligand or chemokine with target-cell receptor, such as CXCR4 and/or CCR5.

54 cl, 2 tbl, 90 ex