2-ARYLIMIDAZO[1,2-b]PYRIDAZINE,2-PHENYLIMIDAZO[1,2-a]PYRIDINE AND 2-PHENYLIMIDAZO[1,2-a]PYRAZINE DERIVATIVES Russian patent published in 2016 - IPC C07D471/04 C07D487/04 A61K31/437 A61K31/4985 A61K31/5025 A61K31/519 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula or a pharmaceutically acceptable salt thereof. Disclosed compounds have inhibitory activity on Hedgehog pathway activation and can be effective in treating pancreatic cancer or prostate cancer. In formula R₁ is a pyridyl, optionally substituted in position where substitution is possible with one or more R₈; R₂ is CN, C₁-C₆ alkyl, C₃-C-₈ cycloalkyl, phenyl, 5-6-member heteroaryl, where 1-2 members are heteroatoms selected from N and O, 4-5-member heterocyclyl, where 1 member is a heteroatom selected from a group consisting of N, where each alkyl, cycloalkyl, phenyl or heterocyclyl group is optionally substituted in position where substitution is possible with one or more R₁₀; R₃ is halogen, C₁-C-₆ alkyl, C₁-C₆ haloalkyl or C₃-C₈ cycloalkyl; A is a bond,-N(R₇)-, -N(R₇)C(O)-, N(R₇)C(O)N(R₇)-, -C(O)O-, -S(O)₂N(R₇)- or-N(R₇)S(O)₂-; each R₅ is independently hydrogen, C₁-C₆ alkyl; each Z is independently CR₆; each R₆ is independently hydrogen, halogen. Invention also relates to a pharmaceutical composition containing disclosed compound, a method of inhibiting Hedgehog signaling pathway and use of compounds.

EFFECT: technical result is obtaining novel compounds having inhibitory activity on Hedgehog pathway activation.

19 cl, 3 dwg, 5 tbl, 706 ex