DERIVATIVES OF TETRAHYDROQUINOLINE SHOWING PROTECTIVE ACTION FROM HIV-INFECTION Russian patent published in 2009 - IPC C07D215/38 C07D403/04 A61K31/47 A61P31/12 

FIELD: medicine.

SUBSTANCE: invention concerns bonds of the general formula , where t it is peer 0, 1 or 2; everyone R independently represents H, alkyl, alkenyl, alkinyl, halogenalkyl, cycloalkyl, -R^aAy, -R^aOR⁵; n it is peer O; R² it is chosen from the group consisting from H, probably substituted alkyl, alkenyl, alkinyl, cycloalkyl, -R^aAy,-R^aOR⁵, and R² is not an amine or an alkylamin, or it is not substituted by an amine or an alkylamin; R³ represents H, probably substituted alkyl, alkenyl, alkinyl, halogenalkyl, cycloalkyl, -R^aAy, -R^aOR⁵ where when p it is peer 0, R³ is not amine or an alkylamin, or it is not replaced by amine or an alkylamin; everyone R⁴ independently represents halogen, alkyl, alkenyl, alkinyl, halogenalkyl, cycloalkyl, cycloalkenyl, -Ay, -NHAy, -Het, -NHHet, -NR⁶R⁷, -R^aNR⁶R⁷, -R^aC(O)R¹⁰, -C(O)R¹⁰, -CO₂R¹⁰, -R^aCO₂R¹⁰, -C(O)NR⁶R⁷, -C(O)Ay, -C(O)Het; m it is peer 0, 1 or 2; every R⁵ independently represents H, alkyl, alkenyl, alkinyl, cycloalkyl, -R^aAy or -Ay; p it is peer 0 or 1; Y represents -NR¹⁰-, -C(O)NR¹⁰-, -NR¹⁰C(O)-, -C(O)-, -C(O)O-, -NR¹⁰C(O)N(R¹⁰)_2-, X represents -N(R¹⁰)₂, -R^aN(R¹⁰)₂, -AyN(R¹⁰)₂, -R^aAyN(R¹⁰)₂, -AyR^aN(R¹⁰)₂, -R^aAyR^aN(R¹⁰)₂, -Het, -R^aHet, -HetN(R¹⁰)₂, -R^aHetN(R¹⁰)₂, -HetR^aN(R¹⁰)₂, -R^aHetR^aN(R¹⁰)₂, HetR^aAy or HetR^aHet, where, when p it is peer 0 then X is not -N(R¹⁰)₂; everyone R^a independently represents probably replaced alkylene, cycloalkylene, alkenylene, cycloalkenylene or alkinilene; every R¹⁰ independently represents H, alkyl, cycloalkyl, alkenyl, alkinyl, cycloalkenyl, -racycloalkyl, -R^aOH, -R^aOR⁵, -R^aNR⁶R⁷ or -R^aHet; each of R⁶ and R⁷ is independently chosen from H, alkyl, cycloalkyl, alkenyl, alkinyl, cycloalkenyl, groups-racycloalkyl, -R^aOH, -R^aOR⁵, -Het, -R^aHet; every Ay independently represents probably substituted aryl group; and every Het independently represents probably substituted 4, 5 either 6-termed heterocycle or eheteroaryl group where heteroatoms are chosen from N and O; to a pharmaceutical composition for treatment and HIV-infection preventive maintenance, to application of bonds formulas I, in medical product manufacturing, and also to ways of reception of bond of the formula I.

EFFECT: rising of efficiency of a composition and the method of treatment.

55 cl, 2 tbl, 185 ex