FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formula (I) and their pharmaceutically acceptable salts of formula (I) 
where n equals 0, 1 or 2, A is a five- or six-member aromatic ring which optionally contains one or two heteroatoms independently selected from nitrogen, oxygen or sulphur, B is a 5-9-member ring containing 0 or 1 double bonds and optionally contains an additional heteroatom selected from nitrogen and oxygen; where the ring optionally contains one or two substitutes independently selected from a group comprising C1-C6-alkoxy, C1-C6-alkoxycarbonyl, C1-C6-alkyl, carboxy, cyano, hydroxy, hydroxy-C1-C6-alkyl, di-C1-C6-alkylamino-C1-C6-alkyl, (NR4R5)-carbonyl or oxo; R1 is selected from -C(O)NR4R5 - CO2R4, 5-tetrazolyl, cyano; each R2 is independently selected from a group comprising C1-C6-alkyl, amino, benzyloxy, halogen, hydroxyl; R3 is a 5-7-member cycloalkyl ring; values of the rest of the radicals are given in the formula of invention. The invention also relates to a method for synthesis of the said compounds, a method of inhibiting HCV replicon function and a method of inhibiting functioning of the HCV NS5B protein.
EFFECT: wider field of use of the compounds.
16 cl, 4 tbl, 29 ex
| Title | Year | Author | Number |
|---|---|---|---|
| IMIDAZO(OR TRIAZOLO)PYRIMIDINE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL AGENT INHIBITING SYK TYROSINE KINASE ACTIVITY | 2001 |
|
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| COMBINATION, INCLUDING A) PYRIMIDYLAMINOBENZAMIDE AND B) KINASE Thr315lle INHIBITOR | 2007 |
|
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| CONDENSED HETEROCYCLIC COMPOUND | 2009 |
|
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| SUBSTITUTED BICYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF INHIBITION | 1998 |
|
RU2204557C2 |
| DERIVATIVES OF AZETHIDINE AS ANTAGONISTS OF CCR-3 RECEPTOR | 2003 |
|
RU2314292C2 |
| OXIME DERIVATIVES AND PREPARATION THEREOF | 2006 |
|
RU2420525C2 |
| PURINE DERIVATIVES AS A RECEPTOR AGONISTS | 2006 |
|
RU2400483C2 |
| SUBSTITUTED BICYCLIC COMPOUNDS, PARENT AND INTERMEDIATE SUBSTANCES FOR THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1998 |
|
RU2203272C2 |
| COMBINED THERAPY INCLUDING SGLT INHIBITORS AND DPP4 INHIBITORS | 2009 |
|
RU2481106C2 |
| PYRIDYLALKENE AND PYRIDYLALKYNE ACID AMIDES, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF ITS PREPARING | 1997 |
|
RU2200734C2 |
