FIELD: chemistry.
SUBSTANCE: claimed invention describes novel chemical compounds possessing ability to slow down blood plasma coagulation, of general structural formula (I), its pharmaceutically acceptable salts or solvates: A-B-C (I), where values of radicals A, C, R9 are such as given in invention formula, R1, R2, R3, R4 independently on each other represent hydrogen or C1-6alkyl; B represents -(CH2)n-, where n takes whole values from 1 to 5; where R5 is selected from group containing hydrogen, C1-6alkoxy, CH2NR10R11, CH(CH3)NR10R11 and other values, given in invention formula, R6 and R7 independently represent hydrogen, C1-6alkyl; C1-6alkoxy; halogen; R8 represents hydrogen or C1-6alkyl; R10, R12 independently on each other are selected from group, consisting of hydrogen, C1-6alkyl; (CH2)mCOOR13, (CH2)mCON(R13)2 and other values given in invention formula, where m takes whole values from 1 to 4, R13 represents hydrogen or C1-6alkyl, R11 represents C1-6alkyl; Ar; Ar represents phenyl, pyridyl, oxazolyl, tiazolyl, tienyl, furanyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, benzofuranyl, benzothiophenyl, substituted from one to five substituents, sele4cted from group: hydrogen, C1-6alkyl, C1-6alkoxy, halogen, N(R13)2, OH, NO2, CN, COOR13, CON(R13)2, SO2R13; application of said compounds as anticoagulants for treatment of thrombotic conditions, based on them pharmaceutical composition and plasma-substituting solution for correction of hypercoagulation disorders.
EFFECT: obtaining novel compounds which can be useful for treatment of thromboembolic complications and prevention of hypercoagulation conditions.
5 cl, 3 tbl, 7 ex, 12 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| DIMETHYL 7-METHYL-2-n-TOLYL-4-PHENYLPYRROLO[2,1-f] [2,1,4]TRIAZINE-5,6-DICARBOXYLATE WITH ANTICOAGULANT EFFECT | 2022 |
|
RU2790375C1 |
| DIRECT THROMBIN INHIBITOR, POSSESSING ANTIPROLIFERATIVE ACTION | 2007 |
|
RU2369615C2 |
| ALMOND ACID DERIVATIVES AND THEIR USE AS THROMBIN INHIBITOR | 2002 |
|
RU2341516C2 |
| SOLUTION FOR CORRECTION OF PRIMARY HOMEOSTASIS DISORDER WITH PLASMA-SUBSTITUTING SOLUTIONS OF NOVEL COMPOSITION | 2005 |
|
RU2300385C1 |
| TRIPEPTIDE DERIVATIVES AS R- OR RS-FORMS OR THEIR PHARMACEUTICALLY ACCEPTABLE NONTOXIC SALTS, PHARMACEUTICAL COMPOSITION | 1991 |
|
RU2077538C1 |
| APTAMER OLIGONUCLEOTIDE - DIRECT THROMBIN INHIBITOR | 2008 |
|
RU2401306C2 |
| MODIFIED DNA APTAMERS INHIBITING THROMBIN ACTIVITY | 2009 |
|
RU2410432C1 |
| STANDARD DRUG PREPARATIONS AND METHODS OF TREATING THROMBOSIS BY ORAL ADMINISTRATION OF FACTOR XA INHIBITOR | 2007 |
|
RU2452484C2 |
| USE OF PINANYLSULFIDE WITH METHYL MERCAPTOACETATE FRAGMENT - METHYL 2-({[(1S,2R,5S)-6,6-DIMETHYLBICYCLO[3.1.1]HEPT-2-YL]METHYL}THIO) ACETATE, AS AN AGENT WITH INHIBITORY EFFECT ON PLATELET ACTIVATION | 2015 |
|
RU2671567C2 |
| SYNTHETIC PEPTIDE DERIVATIVE EXPRESSING ANTICOAGULANT ACTIVITY | 2007 |
|
RU2377246C2 |
