KREATINE AMIDES, METHOD FOR ITS MAKING, NEUROPROTECTIVE AGENT Russian patent published in 2009 - IPC C07C211/13 C07C229/06 C07C229/28 A61K31/16 C07C279/00 

FIELD: chemistry.

SUBSTANCE: invention refers to pharmaceutical chemistry, namely to new biologically active substances (BAS) and to their properties, namely to kreatine derivatives of general formula: NH=C(NH₂)-N(CH₃)-CH₂-CO-NH-R∗X, where R is aminoacid residual of aliphatic, aromatic or heteroaromatic amino acid or its derivative, representing pharmaceutically acceptable salts of amino acids, esters of amino acids, amides of amino acids or peptides; X is low-molecular organic or mineral acid, or water. New substances are produced by interaction of guanydilic agents and sarcosine amides in polar organic solvents at temperature 50°C and less.

EFFECT: new compounds can be used as a neuroprotective agent.

3 cl, 10 ex, 6 tbl