CIS-IMIDAZOLINES AS MDM2 INHIBITORS Russian patent published in 2009 - IPC C07D233/22 C07D401/06 C07D403/06 A61K31/4164 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention refers to a new at least one compound chosen from the compounds of formula where each X₁ and X₂ independently represents -OR₃, R₁ is chosen from the group including C₁-C₈alkyl, C₁-C₄alkyl, attached to (C₄-C₈)cycloalkyl, and C₄-C₈ cycloalkyl, R₂ stands for hydrogen or -C=OR₉, R₃ is chosen from the group including (lower) alkyl and (lower) alkyl substitutted with group R₈, R₈ represents halogen, R₉ represents saturated 6-merous cycle containing at least one heteroatom N, and optionally substituted with the group chosen from (lower) alkyl, -C=O-R₁₁, (lower) alkyl substituted with hydroxygroup, =O, and 5 and 6-merous saturated cycles containing at least one heteroatom N, R₁₁ represents (lower) alkyl, or to its pharmaceutically acceptable salt or to its ester. Besides, the invention concerns a pharmaceutical composition.

EFFECT: production of the new biologically active compounds inhibiting to interaction of protein MDM2 and r-53 with a similar peptide.

14 cl, 60 ex, 1 tbl