NOVEL 2,4-DIAMINOTHIAZOL-5-ONE DERIVATIVES Russian patent published in 2010 - IPC C07D277/42 C07D417/12 A61K31/426 A61K31/427 A61P35/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to compounds of formula I and their pharmaceutically acceptable salts and esters. The disclosed compounds have inhibitory effect on cyclin-dependant kinase. In formula I R¹ denotes , R³ is selected from a group consisting of H, CO₂R⁶, C(O)R⁶, SO₂R⁶ and SO₂NR⁵R⁶, R⁵ and R⁶ are each independently selected from a group which includes H and (lower)alkyl, R² is phenyl which contains one, two or three substitutes independently selected from a group which includes halogen or -O-(lower)alkyl.

EFFECT: preparation of a pharmaceutical composition which contains an effective amount of a formula I compound as an active ingredient.

6 cl, 1 tbl, 22 ex