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(19)

(11)

2 347 782

(13)

(51)

IPC

C07D295/18(2006-01-01)

C07D233/74(2006-01-01)

A61K31/496(2006-01-01)

A61P29/00(2006-01-01)

C07D207/14(2006-01-01)

C07D207/16(2006-01-01)

C07D207/28(2006-01-01)

C07D211/48(2006-01-01)

C07D215/38(2006-01-01)

(21) (22)

Application

2005115964/04, 2003-10-24

(24)

Start date

2003-10-24

(22)

Actual filing date

2003-10-24

(45)

Published

2009-02-27

(72)

Inventor

Boll'Bukk BirgitEhder JergEhn' RisharRevezh LasloShlapbakh AkhimVehl'Khli Rudol'F

(73)

Holder

Novartis Ag

DERIVATIVES OF 1-(4-BENZYLPIPERAZIN-1-YL)-3-PHENYLPROPENONE AND THEIR USE, PHARMACEUTICAL COMPOSITION AND METHOD INHIBITING CHEMOKINE RECEPTORS (CCR-1) Russian patent published in 2009 - IPC C07D295/18 C07D233/74 A61K31/496 A61P29/00 C07D207/14 C07D207/16 C07D207/28 C07D211/48 C07D215/38

Abstract RU 2347782 C2

FIELD: chemistry.

SUBSTANCE: present invention pertains to derivatives of 1-(4-benzylpiperazin-1-yl)-3-phenylpropenone, which are antagonists of the chemokine (CCR-1) receptor, with general formula I or its pharmaceutical salts or ester, where substitutes are defined in the description text. The invented compounds can be used for making pharmaceutical compositions, as well as in pharmaceutics for making medicinal agents, with inhibiting effect on chemokine (CCR-1) receptors.

EFFECT: obtaining compounds, used as medicinal agents, with inhibiting effect on chemokine receptors.

10 cl, 113 ex

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RU 2 347 782 C2

Authors

Boll'Bukk Birgit

Ehder Jerg

Ehn' Rishar

Revezh Laslo

Shlapbakh Akhim

Vehl'Khli Rudol'F

Dates

2009-02-27—Published

2003-10-24—Filed