FIELD: chemistry.
SUBSTANCE: invention refers to chromatography and can be used in optically active drug analysis and study. There is disclosed amlodipine optical isomer separation method by thin-layer chromatography once used as stable phase of silica gel layer with co-graft chiral phase, while mobile phase of organic solvent contains: 4-6 volume fractions of 12-20% aqueous solutions of formaldehyde, 4-5 volume fractions of ethanol, 2-3 fractions of acetonitrile.
EFFECT: high selectivity of separation.
2 cl, 2 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR HPLC-BASED DETERMINATION OF VERAPAMIL ENANTIOMERS IN ACTIVE PHARMACEUTICAL INGREDIENTS, TABLETS AND BLOOD PLASMA SAMPLES | 2008 |
|
RU2395807C1 |
| SORBENT FOR GAS-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS (VERSIONS) AND METHOD FOR USE THEREOF | 2014 |
|
RU2574766C2 |
| ADSORBENT FOR GASCHROMATOGRAPHIC SEPARATION OF ENANTIOMERS | 2015 |
|
RU2574767C1 |
| METHOD FOR OBTAINING ENANTIOSELECTIVE SORBENT | 2017 |
|
RU2642796C1 |
| SORBENT FOR OPTIC ISOMER CHROMATOGRAPHY AND METHOD OF ITS OBTAINMENT | 2006 |
|
RU2348455C2 |
| METHOD FOR SELECTIVE SEPARATION OF SALBUTAMOL RACEMIC MIXTURE | 2017 |
|
RU2667002C1 |
| METHOD OF OBTAINING CHIRAL PLANAR PLATE FOR THIN LAYER CHROMATOGRAPHY OF OPTICAL ISOMERS | 2012 |
|
RU2545315C2 |
| SORBENT FOR SEPARATION OF OPTICAL ISOMERS OF SUBSTANCES AND ANALYSIS THEREOF IN BIOLOGICAL FLUIDS BY HPLC AND PREPARATION METHOD THEREOF | 2014 |
|
RU2592893C2 |
| SORBENT FOR RESOLUTION OF OPTICAL ISOMERS AND A METHOD FOR PREPARATION THEREOF | 2004 |
|
RU2255802C1 |
| METHOD OF OBTAINING THIN-LAYER CHIRAL PLATES FOR PLANAR CHROMATOGRAPHY OF STEREOISOMERS AND THEIR RACEMIC MIXTURES | 2013 |
|
RU2541524C2 |
