SORBENT FOR RESOLUTION OF OPTICAL ISOMERS AND A METHOD FOR PREPARATION THEREOF Russian patent published in 2005 - IPC

FIELD: chromatographic sorbents.

SUBSTANCE: invention relates to chromatographic sorbents, which can be used for analysis and preparative purification of optically active compounds. A novel sorbent for resolution of isomers of optically active compounds is developed containing, as chiral selector, macrocyclic glycopeptide antibiotic eremomycin, vancomycin, ristomycin A, teicoplanine, or their aglycons. Method of immobilization of macrocyclic glycopeptide antibiotics is also developed, which resides in that silica gel in aqueous buffer solution is first treated with 3-glycidoxypropyl(trialkoxy)silane and then, in alkaline aqueous or water-organic solution, above-indicated macrocyclic glycopeptide antibiotic is grafted to epoxy group-modified silica gel.

EFFECT: increased selectivity in enantiomer resolution and simplified preparation procedure.

9 cl, 12 dwg, 5 tbl, 9 ex