THERAPEUTIC COMBINATIONS CONTAINING INHIBITOR OF POLY(ADP-RIBOSE)POLYMERASE Russian patent published in 2009 - IPC A61K31/55 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention concerns medical products and concerns the dosed out form for introduction to a mammal, intended for treatment or prevention of a disease state at a mammal mediated by action of PARP where the dosed out form contains chemical combination of formula 1, its pharmaceutically comprehensible salt or a solvate, or their admixtures, in quantity, effective for maintenance of stable size of concentration in plasma, at least, 5.9 ng/ml of the formula chemical combination within, at least, 24 hours after introduction in an organism of a mammal which is the concentration of an inhibitor suppressing (IC89) consumption of cellular NAD+ on 89% and formation of polymer of poly ADP-ribose, and it is corrected taking into account linkage with a protein. The offered dosed out form provides stable size of concentration in plasma of 5.9 ng/ml of AG-014699 within, at least, 24 hours after introduction in an organism of a mammal.

EFFECT: maintenance of effective treatment and prevention of a disease state at a mammal mediated by PARP action.

85 cl, 4 dwg, 23 tbl, 12 ex