PHARMACEUTICALLY ACCEPTABLE SALTS OF 2-{4-[(3S)-PIPERIDIN-3-YL]PHENYL}-2H-INDAZOLE-7-CARBOXAMIDE Russian patent published in 2013 - IPC C07D401/10 A61K31/454 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to pharmaceutically acceptable salts of amide-substituted indazole, namely to 4-methylbenzene sulphonate (3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidinium; (3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidinium benzene sulphate and 4-methylbenzene sulphonate (3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidinium monohydrate, as well as to stereo isomers and tautomers thereof. Besides, the invention refers to a pharmaceutical composition for treating or preventing the states that can be relieved by poly-ADP-ribosopolymerase (PARP) inhibition, to a combination of salts and an anticancer agent, to using them and to a method of treating or preventing cancer by administering these salts to a patient in need thereof.

EFFECT: there are prepared and described new salts of amide-substituted indazole which are inhibitors of the enzyme poly-ADP-ribosopolymerase (PARP) formerly known as poly-ADP-ribosyntase and poly-ADP-ribosyltransferase.

12 cl, 5 ex, 1 tbl