FIELD: chemistry.
SUBSTANCE: invention relates to novel statin derivatives of formula: or its pharmaceutically acceptable salt or stereoisomer, where: X represents -O-, R represents statin residue of formula:
, Y represents a) straight or branched C1-C20alkylene, mainly C1-C10, optionally substituted with one or more OH;
b)
,
where n equals from 0 to 20, and n1 from 1 to 20; on condition that when Y represents b), group -ONO2 is bonded with -(CH2)n 1;
g)
,
where X2 represents -O, n3 from 1 to 6, mainly from 1 to 4, R2 represents H or CH3.
EFFECT: obtaining compounds which possess anti-inflammatory, antithrombotic and antithrombocytic activity, which allows to use them for production of medication for reduction of cholesterol and triglycerides levels and/or for increasing HDL-C level.
14 cl, 6 tbl, 9 ex
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Authors
Dates
2009-07-27—Published
2004-05-24—Filed