NITROOXYDERIVATIVES OF FLUVASTATIN, PRAVASTATIN, CERIVASTATIN, ATOVASTATIN AND ROSUVASTATIN AS CHOLESTEROL-REDUCING AGENTS WITH IMPROVED ANTI-INFLAMMATORY, ANTITHROMBOTIC, ANTI-THROMBOCYTIC ACTIVITY Russian patent published in 2009 - IPC C07D209/24 C07D207/327 A61K31/40 A61K31/404 A61P3/06 

Abstract RU 2362770 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel statin derivatives of formula: or its pharmaceutically acceptable salt or stereoisomer, where: X represents -O-, R represents statin residue of formula:

, Y represents a) straight or branched C1-C20alkylene, mainly C1-C10, optionally substituted with one or more OH;

b)

,

where n equals from 0 to 20, and n1 from 1 to 20; on condition that when Y represents b), group -ONO2 is bonded with -(CH2)n1;

g)

,

where X2 represents -O, n3 from 1 to 6, mainly from 1 to 4, R2 represents H or CH3.

EFFECT: obtaining compounds which possess anti-inflammatory, antithrombotic and antithrombocytic activity, which allows to use them for production of medication for reduction of cholesterol and triglycerides levels and/or for increasing HDL-C level.

14 cl, 6 tbl, 9 ex

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RU 2 362 770 C2

Authors

Benedini Francheska

Ongini Ehnnio

Del' Soldato P'Ero

Dates

2009-07-27Published

2004-05-24Filed