METHOD OF PRODUCTION OF MEVALONIC ACID DERIVATIVES INHIBITING HMG-COA REDUCTASE Russian patent published in 2008 - IPC C07D309/30 C07F15/02 C07F9/50 A61P3/06 

FIELD: chemistry.

SUBSTANCE: invention concerns improved method of obtaining mevalonic acid derivatives of the general formula I or its pharmaceutically acceptable salt with base, or lactone, where -CH₂-CH₂- or -CH=CH-, R is heterocyclical residual of interaction of compound of the general formula IIa , where R₁, R₂, R₃, R₄ meanings are described in the invention, with compound of the general formula IIb: R-CH(=O) where R is cyclical residual. Obtained compound is recovered in the presence of recovery agent, preferably a compound of the formula IId , where M is Ru, Rh, Ir, Fe, Co, Ni, L₁ - H, L₂ - aryl, R₅ is aliphatic residual, R₈ and R₉ are C₆H₅ or form cyclohexane ring or cyclohexane or cyclopentane ring combined with C atom, to which they are bound, with a number of further stages.

EFFECT: high product output.

4 cl, 1 ex