CRYSTALLINE FORM OF CALCIUM SALT OF BIS-[(E)-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[METHYL(METHYLSULPHONYL)AMINO]-PYRIMIDIN-5-YL](3R, 5S)-3, 5-DIHYDROXYHEPT-6-ENOIC ACID Russian patent published in 2009 - IPC C07D239/42 A61K31/505 A61P3/06 

FIELD: chemistry.

SUBSTANCE: according to the invention the new hydrate and dehydrate polymorphic forms of calcium salt of bis-[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulphonyl)amino]-pyrimidin-5-yl](3R, 5S)-3, 5-dihydroxyhept-6-enoic acid general formula are proposed. They can be used for treatment of the diseases demanding of inhibition of the ferment HMG-CoA of 3-dihydroxy-3-methylglutaryl-coenzyme A-reductase), in particular such diseases as hyperlipedimia, hyperholesterinemia, atherosclerosis et al., and to the methods of preparation and application thereof. The crystalline hydrate form B of the said compound has the X-ray diffraction pattern on the powder obtained with the Cu-radiation source featured with the angles 2θ equal to 8.8, 13.1 and 21.5°. The crystalline dehydrate form B1 of the said compound has the X-ray diffraction pattern on the powder obtained with the Cu-radiation source characterised by the angles 2θ equal to 4.4, 7.7, 9.0 and 20.7°.

EFFECT: invention refers also to amorphous form.

16 cl, 4 dwg, 4 ex