FIELD: chemistry.
SUBSTANCE: invention refers to the new compounds of formula I 
in the form of the salt or zwitter-ion, wherein R1 and R3 are independently phenyl, C3-C8 cycloalkyl or thienyl group, R2 is haloid or hydroxyl group; R4 is C1-C8 alkyl substituted with -NR5-CO-R6 or -CO-NR9R10; R5 is hydrogen ; R6 is C1-C8alkyl or C1-C8 alkoxy, each of them is optionally substituted with 5- or 6-membered heterocyclic group containing at least one ring heteroatom selected from nitrogen, oxygen and sulphur, or R6 is 5-10-membered heterocyclic group containing at least one ring heteroatom selected from nitrogen, oxygen and sulphur; R9 is hydrogen or C1-C8alkyl; R10 is C1-C8alkyl, optionally substituted with cyano group, C1-C8 alkoxy group or with 5- or 6-membered heterocyclic group containing at least one ring heteroatom selected from nitrogen, oxygen and sulphur, or R10 is 5-9-membered heterocyclic group containing at least one ring heteroatom selected from nitrogen, oxygen and sulphur. The invention refers also to the pharmaceutic composition, to the application of compound of any of claims 1-5 as well as to the preparation method of compound of formula I of claim 1.
EFFECT: preparation of the new biologically active compounds taking the effect of muscarin receptor M3.
9 cl, 247 ex, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| INHIBITIN CDK-KINASES PYRIMIDINES AND THEIR APPLICATION AS MEDICINES | 2002 |
|
RU2330024C2 |
| PYRIMIDINE DERIVATIVES | 2003 |
|
RU2324684C2 |
| 5-PHENYLTIAZOL DERIVATIVES AND THEIR APPLICATION IN CAPACITY OF P13 KINASE INHIBITORS | 2003 |
|
RU2378263C2 |
| PURINE DERIVATIVES AS A RECEPTOR AGONISTS | 2006 |
|
RU2400483C2 |
| COMPOSITION FOR COLORING KERATIN FIBERS, PARTICULARLY, MAN'S HAIR, METHOD OF COLORING, AND PACKAGING OF KIT FOR COLORING KERATIN FIBERS | 1999 |
|
RU2166311C2 |
| PURINE DERIVATIVES AS INHIBITORS OF TYROSINE PROTEINASE SYK | 2000 |
|
RU2248977C2 |
| PYRROLIDINIUM DERIVATIVES AS M3 MUSCARINIC RECEPTORS | 2005 |
|
RU2412183C2 |
| NICOTINAMIDE DERIVATIVES, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND USING | 2003 |
|
RU2309951C2 |
| QUATERNARY AMMONIUM SALTS AS M3 ANTAGONISTS | 2005 |
|
RU2394031C2 |
| PYRROLOPYRAZINES SUITABLE AS AURORA A KINASE INHIBITORS | 2005 |
|
RU2394825C2 |
