PYRROLOPYRAZINES SUITABLE AS AURORA A KINASE INHIBITORS Russian patent published in 2010 - IPC C07D487/04 A61K31/4985 A61K31/5377 A61K31/506 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, where X is CH; R¹ is phenyl or a 6-member heteroaryl which contains 1 or 2 nitrogen atoms as heteroatoms, independently and optionally substituted with up to five groups J; R² and R³ each independently represents hydrogen, halogen, -V-R or -V-R^a; R⁵ is R; R is H or an optionally substituted C_1-6aliphatic group, where the substitutes are selected from -OR⁰, phenyl, substituted R⁰, -N(R⁰)₂; where each independent R⁰ is selected from hydrogen, halogen, C_1-6aliphatic group; R^a is morpholine, V is a bond or Q; Q is -NR⁵-; each J group independently represents a halogen, -N(R⁵)₂. The invention also relates to a pharmaceutical composition with protein kinase inhibiting properties, and to methods of inhibiting Aurora A protein kinase using the said compounds.

EFFECT: obtaining novel compounds and pharmaceutical compositions based on the said compounds, which can be used in medicine to treat or alleviating a proliferative disorder, such as cancer, in a patient.

25 cl, 2 tbl, 2 ex