METHOD FOR PREPARING SPECIFIC IMMUNOMODULATOR Russian patent published in 2009 - IPC A61K39/04 C12N1/20 C12R1/32 

FIELD: medicine.

SUBSTANCE: BCG strain is cultivated with the prepared culture sonicated. Further antigenic complex representing cytoplasmic and cell membranes is recovered from said sonicated culture. At 15000 rpm, made supernatant fluid (namely the antigenic complex) is mixed with formalin. The reaction mixture is incubated at temperature 37°C in a thermostat, analysed for protein content, and conjugated with polyvinylpyrrolidone (PVP) in mass ratio of protein 1 mg/ml - PVP 600 mg (1:600) in a magnetic stirrer at a room temperature until homogeneous liquid is made.

EFFECT: specific immunomodulatory is capable to restore lost immune responsiveness, to eliminate secondary immunodeficiency, to strengthen protective properties of BCG vaccine.

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