METHOD OF OBTAINING SPECIFIC IMMUNOMODULATOR Russian patent published in 2013 - IPC A61K39/04 A61K47/48 

Abstract RU 2478399 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of veterinary microbiology and deals with method of obtaining specific immunomodulator. Claimed method includes the following stages: cultivation of vaccine strain of BCG, destruction of culture with ultrasound, separation of antigenic complex, mixing supernatant liquid with formalin and conjugation of reaction mixture on polyelectrolytes: polyvinylpyrrolidone (PVP) four parts and polyethyleneglycol (PEG) one part by weight, at ratio 1 mh/ml of protein - 480 mg PVP and 120 mg of PEG by weight on magnetic mixer at room temperature until homogenous liquid is obtained.

EFFECT: invention makes it possible to restore impaired immune reactivity, remove secondary immune deficits, obtain harmless for animals substances, which possess expressed protective properties.

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RU 2 478 399 C2

Authors

Bazhin Mikhail Aristoklevich

Novikov Artem Nikolaevich

Vlasenko Vasilij Sergeevich

Nevorotova Galina Petrovna

Petrov Stanislav Jur'Evich

Shuliko Elena Mikhajlovna

Nazarova Valentina Aleksandrovna

Dates

2013-04-10Published

2011-06-16Filed