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2 478 399

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IPC

A61K39/04(2006-01-01)

A61K47/48(2006-01-01)

(21) (22)

Application

2011124695/10, 2011-06-16

(24)

Start date

2011-06-16

(22)

Actual filing date

2011-06-16

(45)

Published

2013-04-10

(72)

Inventor

Bazhin Mikhail AristoklevichNovikov Artem NikolaevichVlasenko Vasilij SergeevichNevorotova Galina PetrovnaPetrov Stanislav Jur'EvichShuliko Elena MikhajlovnaNazarova Valentina Aleksandrovna

(73)

Holder

Gosudarstvennoe Nauchnoe Uchrezhdenie Vserossijskij Nauchno-Issledovatel'Skij Institut Brutselleza I Tuberkuleza Zhivotnykh Rossijskoj Akademii Sel'Skokhozjajstvennykh Nauk Vniibtzh Rossel'Khozakademii)

METHOD OF OBTAINING SPECIFIC IMMUNOMODULATOR Russian patent published in 2013 - IPC A61K39/04 A61K47/48

Abstract RU 2478399 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of veterinary microbiology and deals with method of obtaining specific immunomodulator. Claimed method includes the following stages: cultivation of vaccine strain of BCG, destruction of culture with ultrasound, separation of antigenic complex, mixing supernatant liquid with formalin and conjugation of reaction mixture on polyelectrolytes: polyvinylpyrrolidone (PVP) four parts and polyethyleneglycol (PEG) one part by weight, at ratio 1 mh/ml of protein - 480 mg PVP and 120 mg of PEG by weight on magnetic mixer at room temperature until homogenous liquid is obtained.

EFFECT: invention makes it possible to restore impaired immune reactivity, remove secondary immune deficits, obtain harmless for animals substances, which possess expressed protective properties.

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RU 2 478 399 C2

Authors

Bazhin Mikhail Aristoklevich

Novikov Artem Nikolaevich

Vlasenko Vasilij Sergeevich

Nevorotova Galina Petrovna

Petrov Stanislav Jur'Evich

Shuliko Elena Mikhajlovna

Nazarova Valentina Aleksandrovna

Dates

2013-04-10—Published

2011-06-16—Filed