FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of veterinary microbiology and deals with method of obtaining specific immunomodulator. Claimed method includes the following stages: cultivation of vaccine strain of BCG, destruction of culture with ultrasound, separation of antigenic complex, mixing supernatant liquid with formalin and conjugation of reaction mixture on polyelectrolytes: polyvinylpyrrolidone (PVP) four parts and polyethyleneglycol (PEG) one part by weight, at ratio 1 mh/ml of protein - 480 mg PVP and 120 mg of PEG by weight on magnetic mixer at room temperature until homogenous liquid is obtained.
EFFECT: invention makes it possible to restore impaired immune reactivity, remove secondary immune deficits, obtain harmless for animals substances, which possess expressed protective properties.
6 tbl
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RU2217164C2 |
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RU2146533C1 |
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Authors
Dates
2013-04-10—Published
2011-06-16—Filed