IMMUNOBIOLOGICAL BACTERICIDAL PREPARATION (VERSIONS) Russian patent published in 2009 - IPC C12N7/00 A61K35/76 A61P31/04 

FIELD: medicine biologically active additives.

SUBSTANCE: According to the invention, the immunobiological bactericidal preparation contains species-specific virulent bacteriophages and induced-virulence bacteriophages of Appelman's lytic activity at least 10^-4 with respect to test strains and bacteria isolates recovered from a human body in filtrate, concentrate filtrate or in a dry biomass of a phage lysate filtrate of nonlysogenic bacteria and pharmaceutically acceptable desired additives. The preparation can be presented as ointment, suppository, powder, tablet or capsule. Declared immunobiological bactericidal preparation is prepared by sequential multiple passages of phages of bacteriophage preparations through test strains and nonlysogenic bacteria isolates fresh-recovered from a human body with an inducing agent, eg mitomycin C, added to nutrient medium. According to the invention, the immunobiological bactericidal preparation provides stable virulence of bacteriophages and adaptation thereof to circular agents of bacterial infections.

EFFECT: higher clinical effectiveness.

13 cl, 9 tbl, 30 ex