ORAL COMPOSITION CONTAINING NONPATHOGENIC MICROORGANISMS SHOWING ABILITY TO NORMALISE INTESTINAL MICROFLORA (VERSIONS) Russian patent published in 2012 - IPC A61K35/66 A61P1/14 

FIELD: medicine.

SUBSTANCE: group of inventions refers to pharmaceutical industry and medicine and is applicable for producing and using medical immunobiological preparations containing nonpathogenic microorganisms. The compositions (versions) represent a powder containing substances containing nonpathogenic microorganisms dried up in a culture medium specified in a number: Bifidobacterium bacteria and/or Lactobacillus bacteria, and/or species-specific virulent bacteriophages, and/or species-specific bacteriophages with induced virulence or their combinations with the composition containing target additives able to form a stable foam structure, is characterised by porous structure and fragility, has a relative disintegration shrinkage at least 10 %, equivalent pore diameter 10-110 mcm at particle size no more than 100 mcm and a resting angle less than 50° in the following proportions in 1.0 g of the composition: Bifidobacterium bacteria 10⁶-10¹⁰ CFU and/or Lactobacillus bacteria 10⁶-10¹⁰ CFU, and/or species-specific virulent bacteriophages of Appelman's lytic activity at least 10^-4 with respect to test strains and bacterial isolates recovered from a human body, and/or species-specific bacteriophages of induced virulence of Appelman's lytic activity at least 10^-4 with respect to test strains and bacterial isolates recovered from a human body, target additives - the rest.

EFFECT: invention provides maximally achieved isotropic filling of the set volume of drug containers that provides accurate dosage of nonpathogenic microorganisms.

7 cl, 9 ex